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Cellular experiments demonstrated that left\u2010handed titanium dioxide NPs (\n                    <jats:italic>L<\/jats:italic>\n                    \u2010TiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs) enter MODE\u2011K intestinal epithelial cells via toll\u2011like receptor 4 and trigger the generation of intracellular reactive oxygen species (ROS), which activating the nuclear factor\u2011\u03baB and NOD\u2011like receptor thermal protein domain\u2011associated protein 3 (NLRP3) signaling pathway to drive the release of inflammatory mediators, which subsequently induced epithelial\u2011mesenchymal transition (EMT) in 4T1\u2011luc breast cancer cells and remodel the lung microenvironment, significantly enhancing the migration and adhesion of 4T1\u2011luc cells to 3B\u201111 lung endothelial cells, verified in a mouse model of breast cancer, indicating that\n                    <jats:italic>L<\/jats:italic>\n                    \u2010TiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs not only increased the migratory and invasive capacities of the primary tumor, but also shaped a microenvironment in the lungs that facilitated the colonization of circulating tumor cells (CTCs), thereby driving the acceleration of breast cancer lung metastasis. This work systematically elucidates that chiral TiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs regulate the distal microenvironment through the ROS\u2010inflammatory signaling cascade to accelerate lung metastasis of breast cancer, suggesting that the risk of inducing tumor metastasis should be carefully evaluated when designing chiral nanomedicines.\n                  <\/jats:p>","DOI":"10.1002\/adma.74340","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:40:03Z","timestamp":1785307203000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chiral Titanium Dioxide Nanoparticles Induce Breast Cancer Lung Metastasis"],"prefix":"10.1002","volume":"38","author":[{"given":"Dayu","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology International Joint Research Laboratory for Biointerface and 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