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Inspired by\n                    <jats:italic>Turritopsis nutricula<\/jats:italic>\n                    , we directly fabricated biomimetic skin matrix (BSM) from human adipose tissue (AT) by decellularization, then incorporated with amino\u2010functionalized apoptotic bodies (FABs) to construct a biomimetic skin (BSM@FABs). BSM@FABs effectively displayed high fibroblast affinity while reversing cellular senescence, accelerating migration, and stimulating neovascularization in aged wounds. Mechanistically, we identified a pioneering DAZAP1 liquid\u2010liquid phase separation (LLPS) triggered by BSM@FABs. These biomolecular condensates in the LLPS process enhanced tricarboxylic acid (TCA) cycle flux and oxidative phosphorylation (OXPHOS), concomitant with suppressed glycolysis and reduced mitochondrial reactive oxygen species, thereby resolving aging\u2010impaired mitochondrial dysfunction. Our work introduces a novel LLPS\u2010targeted strategy for aged wound treatment by reprogramming mitochondrial energy metabolism.\n                  <\/jats:p>","DOI":"10.1002\/adma.74352","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T21:33:02Z","timestamp":1785015182000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Turritopsis nutricula<\/i>\n                    \u2010Inspired Engineered Biomimetic Skin Promoting Aged Wound Repair via DAZAP1 Phase Separation\u2010Related Mitochondrial Metabolism Reprogramming"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0757-6598","authenticated-orcid":false,"given":"Chen","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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