{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:28:38Z","timestamp":1790782118633,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"53","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22365022"],"award-info":[{"award-number":["22365022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304409"],"award-info":[{"award-number":["82304409"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2022QN03014"],"award-info":[{"award-number":["2022QN03014"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004763","name":"Natural Science Foundation of Inner Mongolia Autonomous Region","doi-asserted-by":"publisher","award":["2023QN03005"],"award-info":[{"award-number":["2023QN03005"]}],"id":[{"id":"10.13039\/501100004763","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003850","name":"Inner Mongolia University","doi-asserted-by":"publisher","award":["SYXK 2020\u20100006"],"award-info":[{"award-number":["SYXK 2020\u20100006"]}],"id":[{"id":"10.13039\/501100003850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The clinical translation of extracellular matrix (ECM)\u2010mimetic protein hydrogels is often hampered by their inadequate mechanical strength and structural disorder. Innovative strategies that integrate structural control with bioactive cues are urgently needed for diabetic wound repair. We present a synergistic \u201ctopological engineering\/metal\u2010coordination\u201d strategy to design a new class of collagen\u2010like protein hydrogels. Via genetic encoding, metal\u2010binding domains (Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    , Ag\n                    <jats:sup>+<\/jats:sup>\n                    , Cu\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    ), together with a cell\u2010adhesive RGD motif and stabilizing V\u03b1\/V\u03b2 domains, were incorporated into collagen scaffolds (CLP3\/CLP1). We further engineered hydrogels with precisely defined point\u2010, cyclic\u2010, and bis\u2010cyclic\u2010crosslinked topologies. The Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    \u2010coordinated, bis\u2010cyclic\u2010crosslinked hydrogel based on CLP3 (BZnC\u03b13) exhibited optimal integrated performance. It demonstrated skin\u2010like stress\u2010strain curves, superior toughness, and excellent fatigue resistance. In vitro, BZnC\u03b13 promoted cell adhesion, proliferation, migration, and exhibited potent antibacterial and anti\u2010inflammatory effects. In a diabetic mouse model, BZnC\u03b13 significantly accelerated wound closure, enhanced re\u2010epithelialization and collagen deposition, and orchestrated a pro\u2010healing microenvironment by polarizing macrophages to the M2 phenotype, upregulating regenerative factors, and alleviating oxidative stress. This work establishes a genetically encoded platform for creating protein hydrogels with tunable topology and dynamic mechanics, emerging as a multifaceted biomaterial that effectively addresses mechanical and biological barriers, holding great promise as a therapeutic dressing for refractory diabetic wounds.\n                  <\/jats:p>","DOI":"10.1002\/adma.74363","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:18:32Z","timestamp":1785233912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Synergistically Engineered Protein Hydrogel Integrating Topological Reinforcement and Metal\u2010Ion Coordination for Diabetic Wound Repair"],"prefix":"10.1002","volume":"38","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Inner Mongolia Key Laboratory For Molecular Regulation of the Cell School of Life Sciences Inner Mongolia University  Hohhot P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Wang","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory For Molecular Regulation of the Cell School of Life Sciences Inner Mongolia University  Hohhot P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Sun","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory For Molecular Regulation of the Cell School of Life Sciences Inner Mongolia University  Hohhot P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Inner Mongolia Key Laboratory For Molecular Regulation of the Cell School of Life Sciences Inner Mongolia University  Hohhot P. R. 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