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Here, we present a thermally resilient metal\u2010organic framework encapsulated microneedle (MOF@MN) sensing platform that integrates minimally invasive dermal interstitial fluid (ISF) sampling and on\u2010needle detection with MOF\u2010based biostabilization of the sensing interface. A thin zeolitic imidazolate framework\u20108 (ZIF\u20108) shell is grown in situ on antibody\u2010functionalized microneedles, preserving the bioactivity of immobilized antibodies after 4 weeks of thermal cycling up to 50\u00b0C and maintaining full analytical performance after prolonged unrefrigerated shipment. This interfacial encapsulation strategy enables quantitative detection of neutrophil gelatinase\u2010associated lipocalin (NGAL), an early biomarker of kidney injury, directly from dermal ISF over a broad clinically relevant range. In a mouse model and human subjects, MOF@MN\u2010derived NGAL measurements closely mirror blood NGAL concentrations, precede changes in conventional renal function markers, and correlate well with histopathological injury severity, highlighting their potential for subclinical monitoring. Collectively, this study establishes conformal MOF encapsulation as a simple and highly effective strategy for engineering environmentally resilient sensing interfaces and provides a scalable route to cold\u2010chain\u2010independent, minimally invasive biosensing for decentralized and at\u2010home health monitoring.<\/jats:p>","DOI":"10.1002\/adma.74423","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T12:20:51Z","timestamp":1785932451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metal\u2013Organic Framework\u2010Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2518-0699","authenticated-orcid":false,"given":"Yixuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Materials 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