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Here, we report an auxin\u2010functionalized nanocarrier strategy that enables programmable systemic transport by interfacing engineered materials with plant signaling networks. Nanocarrier dimensions were tuned to \u223c55\u00a0nm to limit endocytosis and favor extracellular localization, while auxin motifs were introduced on the particle surface. This design establishes a predominantly extracellular interface that hijacks polar auxin transport pathways. As a result, PIN\u2010mediated fluxes are enhanced, accompanied by a 10.42\u2010fold upregulation of PIN1, enabling directional leaf\u2010to\u2010root transport over centimeter scales and a 72.32\u2010fold increase in root accumulation. This signal\u2010coupled transport mechanism enables efficient root\u2010targeted delivery of agrochemical cargos (abamectin) via foliar application, achieving up to 79.71% control of root\u2010knot nematodes while reducing pesticide input by half. Furthermore, bypassing soil application provides a 3.20\u2010fold higher ecological safety margin and yields a 16.47% increase in crop production. Beyond this application, the work establishes a generalizable design principle in which synthetic materials exploit endogenous signaling frameworks to navigate biological transport systems, opening new opportunities for systemic crop protection and bio\u2010integrated material delivery.<\/jats:p>","DOI":"10.1002\/adma.74440","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T09:58:55Z","timestamp":1785751135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Auxin\u2010Functionalized Nanocarriers Hijack Endogenous Transport for Systemic Crop Protection in Plants"],"prefix":"10.1002","volume":"38","author":[{"given":"Xi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Applied Chemistry College of Science China Agricultural University  Beijing P. R. China"},{"name":"Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests Ministry of Education School of Tropical Agriculture and Forestry Hainan University  Danzhou Hainan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Xia","family":"Bai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests Ministry of Education School of Tropical Agriculture and Forestry Hainan University  Danzhou Hainan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry College of Science China Agricultural University  Beijing P. R. 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