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However, conventional IOLs exhibit limited biological adaptability and fixed or discontinuous focal properties, preventing restoration of the natural lens's continuous accommodation and often causing postoperative visual disturbances and complications. Herein, we report an injectable multifunctional hydrogel\u2010based biomimic lens that simultaneously reconstructs optical\u2013mechanical properties and dynamically modulates the postoperative lenticular microenvironment. Through multilayered dynamic crosslinking and micro\u2010capsulorhexis\u2010assisted in situ gelation within the capsular bag, the hydrogel forms a biomimic lens with continuous refractive characteristics. Meanwhile, its drug\u2010loading capability enables the incorporation of multifunctional components for early postoperative antibacterial, anti\u2010inflammatory, and antifibrotic effects. In addition, after inflammation subsides, the loaded photocatalytic elements induce the orderly clearance of residual lens epithelial cells, enabling comprehensive restoration of microenvironmental homeostasis within the capsular bag. In a rabbit model, this hydrogel lens demonstrates effective refractive reconstruction and sustained suppression of postoperative complications, highlighting its potential as a next\u2010generation intraocular lens.<\/jats:p>","DOI":"10.1002\/adma.74450","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T16:34:33Z","timestamp":1785602073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multifunctional Injectable Hydrogel as a Biomimic Lens: Optical\u2013Mechanical Restoration and Dynamic Postoperative Microenvironment Regulation"],"prefix":"10.1002","volume":"38","author":[{"given":"Renjie","family":"Zhang","sequence":"first","affiliation":[{"name":"National Engineering Research Center of Ophthalmology and Optometry School of Biomedical Engineering School of Ophthalmology and Optometry Eye Hospital Wenzhou Medical University  Wenzhou 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