{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:58:18Z","timestamp":1791475098638,"version":"4.3.4"},"reference-count":29,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372114"],"award-info":[{"award-number":["82372114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Prostate cancer (PCa) remains a major clinical challenge due to therapeutic resistance and immunologically cold tumor microenvironment. Lysosomal membrane permeabilization (LMP)\u2013induced lysosome\u2010dependent cell death offers an alternative route to eliminate resistant tumor cells and initiate immunogenic cell death, yet its efficacy is often limited by insufficient spatiotemporal control and immune activation. Here, we report a spatiotemporally programmable supramolecular nanoplatform (Cu\u2010P\u2010MSA) that integrates lysosome\u2010targeted sonodynamic therapy with tumor\u2010confined innate immune activation for PCa treatment. Cu\u2010P\u2010MSA is a modular self\u2010assembling peptide incorporating a PSMA\u2010targeting ligand, morpholine moiety, and cathepsin B\u2013cleavable linker, enabling tumor\u2010selective uptake and in situ formation of fibrous sonosensitizer depots within lysosomes. Upon ultrasound irradiation, a glutathione\u2010responsive open\u2010shell sonosensitizer induces controlled LMP, simultaneously activating ferroptosis and pyroptosis and promoting immunogenic cell death. Meanwhile, tumor\u2010specific release of a STING agonist MSA\u20102 elicits robust type I interferon responses, driving dendritic cell maturation and cytotoxic T\u2010cell infiltration. This coordinated lysosomal disruption\u2013immune amplification strategy effectively reprograms the tumor immune microenvironment and suppresses both primary and distant tumors, with inhibition rates reaching 84.3% and 77.5%, respectively. Overall, this work establishes a spatiotemporally controlled supramolecular approach that integrates lysosomal disruption with innate immune activation to overcome therapeutic resistance and immunosuppression in PCa.<\/jats:p>","DOI":"10.1002\/adma.74477","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:11:47Z","timestamp":1785921107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spatiotemporally Controlled Lysosomal Membrane Permeabilization Amplifies STING\u2010Driven Antitumor Immunity in Prostate Cancer"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3792-9959","authenticated-orcid":false,"given":"Qishu","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicheng","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Chemistry China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3931-0439","authenticated-orcid":false,"given":"Wenying","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Chemistry China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Urology Urologic Surgery Center Xinqiao Hospital Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"Chongqing Engineering Research Center of Tumor Biomarker Translation Third Military Medical University (Army Medical University)  Chongqing China"},{"name":"State Key Laboratory of Trauma and Chemical Poisoning Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010med\u2010051517\u2010011947"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.12.008"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010023\u201000973\u20108"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101199"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01638"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon\u20102019\u20100068"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201017\u20100019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41391\u2010021\u201000340\u20105"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010024\u201000920\u20109"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010025\u201003569\u20103"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201008204\u20109"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056494\u20106"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010019\u20101883\u20108"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010025\u201010997\u2010z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201004912\u20108"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307679"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c01922"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c17268"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201205482"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202302093"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00403D"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12613"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110283"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010022\u201000468\u2010w"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201805798"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00306"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201804971"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309054"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:30:45Z","timestamp":1791473445000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":29,"journal-issue":{"issue":"56","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.74477"],"URL":"https:\/\/doi.org\/10.1002\/adma.74477","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74477"}}