{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:59:06Z","timestamp":1792051146681,"version":"4.4.0"},"reference-count":63,"publisher":"Wiley","issue":"56","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022033"],"award-info":[{"award-number":["82022033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Provincial Science and Technology Support Program","doi-asserted-by":"publisher","award":["2024NSFJQ0048"],"award-info":[{"award-number":["2024NSFJQ0048"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Currently, the elimination of postsurgical osteosarcoma (OS) and defect repair are still separately explored, which is unlike real\u2010world clinical scenarios. Inadequate bone marrow stromal cells (BMSCs) compromise their repair and antitumor efficiencies. Here, PFSSTKT (PFS)\u2010functionalized KLD\u201012 peptide hydrogels (KLD\u2010PFS) have been engineered and integrated with 2D BiOIO\n                    <jats:sub>3<\/jats:sub>\n                    nanosheets to obtain the injectable sono\u2010piezoelectric\/pyroelectric peptide hydrogels (KLD\u2010PFS@BiOIO\n                    <jats:sub>3<\/jats:sub>\n                    ) featuring a supramolecular peptide nanofiber (SMPNF) structure. Differing from the dominant BaTiO\n                    <jats:sub>3<\/jats:sub>\n                    in sono\u2010piezoelectric dynamic therapy (SPDT) of cancer, BiOIO\n                    <jats:sub>3<\/jats:sub>\n                    nanosheets can produce ROS through sono\u2010piezoelectric and pyroelectric catalytic processes under ultrasound irradiation, thus enabling the combination of SPDT with pyroelectric dynamic therapy against residual OS. More significantly, PFS as a bone marrow homing peptide enables KLD\u2010PFS to capture and recruit more BMSCs, and the inherent SMPNF structure, direct ultrasound\u2010induced current stimuli, sono\u2010piezoelectricity\/pyroelectricity\u2010induced current stimuli and ROS birth expedite BMSCs differentiation and bone regeneration. These multifaceted actions follow the signaling pathways associated with calcium flux and cancer\u2013neuron communication disruptions and metabolic dysfunction rectification. They have been successfully validated to repress residual OS and favor bone regeneration in a clinical scenarios\u2010matched postsurgical osteosarcoma and bone defect model. This study offers a promising strategy for comprehensive osteosarcoma management.\n                  <\/jats:p>","DOI":"10.1002\/adma.74522","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T09:28:07Z","timestamp":1785922087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stromal Cells Recruitment by Sono\u2010Piezoelectric\/Pyroelectric Peptide Hydrogels Promotes Bone Regeneration After Postsurgical Osteosarcoma Recession: A Real\u2010World\u2010Matched Study"],"prefix":"10.1002","volume":"38","author":[{"given":"Qilong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"Department of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai China"},{"name":"Department of Ultrasonography The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taixia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"Department of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7672-0053","authenticated-orcid":false,"given":"Huaijuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"Department of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-3864","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Shanghai Engineering Research Center of Lung Transplantation Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujia","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6646-8888","authenticated-orcid":false,"given":"Haowen","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5528-8353","authenticated-orcid":false,"given":"Shihao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2653-3342","authenticated-orcid":false,"given":"Ruonan","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-1942","authenticated-orcid":false,"given":"Chao","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"Department of Thoracic Surgery Shanghai Engineering Research Center of Lung Transplantation Shanghai Pulmonary Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Department of Medical Ultrasound Shanghai Tenth People's Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-1164","authenticated-orcid":false,"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan China"},{"name":"State Key Laboratory of Targeting Oncology, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy National Center for International Research of Biotargeting Theranostics Guangxi Key Laboratory of Biotargeting Theranostics Guangxi Medical University  Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.024"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104142"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6661534"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmatsci.2023.101230"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40820\u2010024\u201001533\u2010y"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408016"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.07.004"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002430\u20107"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08738"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4483"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202406639"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010022\u201000780\u20101"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202315394"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122662"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/accountsmr.2c00106"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c12614"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202301784"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300648"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01856"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202405741"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201053392\u20101"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312032"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.01.003"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300313"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202425565"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2026.103010"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101143\u2010y"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.07.007"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040954\u2010y"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2021.105895"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300338"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901511"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja205456b"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2021.05.151"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202403979"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103820"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26981"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202316675"},{"key":"e_1_2_13_41_1","article-title":"Regulatory Mechanisms and Regeneration Strategies of the Soft\u2013Hard Tissue Interface in the Human Periodontium","volume":"2","author":"Dang G.","year":"2024","journal-title":"BioMedical Engineering Materials"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.156003"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2022.214824"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215115"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202300437"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b02404"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202201134"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202415814"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202413171"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201900099"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202208128"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203921"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.08.025"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2688"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6010436"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202424326"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi8602"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010023\u201004652\u20101"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.06.018"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010024\u201006435\u2010w"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.784"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010023\u201001284\u20109"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2025.102366"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202420394"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74522","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74522","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74522","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:29:45Z","timestamp":1791473385000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":63,"journal-issue":{"issue":"56","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.74522"],"URL":"https:\/\/doi.org\/10.1002\/adma.74522","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"2026-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74522"}}