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To address this, we developed a multifunctional hydrogel (Gel\u2010PDZC), through an artificial neural network (ANN)\u2010guided optimization process, incorporating nanoparticles comprising a ZIF\u20108@CaO\n                    <jats:sub>2<\/jats:sub>\n                    core for sustained oxygen release, a polydopamine (PDA) interlayer for adhesion and antioxidant activity, and a conductive poly(3,4\u2010ethylenedioxythiophene) (PEDOT) shell. The hydrogel exhibits a unique \u201cadhesion\u2010electrocoupling\u201d effect, where robust tissue adhesion facilitates a pseudocapacitive charge injection mechanism. This not only enables active electrical intervention in the avascular scar but also leverages the endogenous myocardial electric field to restore the hydrogel's antioxidant properties. In a rat MI model, the Gel\u2010PDZC hydrogel comprehensively remodeled the myocardial interstitial microenvironment. It alleviated hypoxia, reduced oxidative stress and apoptosis, suppressed pro\u2010inflammatory C\u2010C motif chemokine receptor 2 (CCR2\n                    <jats:sup>+<\/jats:sup>\n                    ) macrophages recruitment and promoted electrical coupling between resident CCR2\n                    <jats:sup>\u2212<\/jats:sup>\n                    macrophages and cardiomyocytes (CMs), inhibited fibroblast\u2010to\u2010myofibroblast transition via the PI3K\/AKT pathway, and stimulated angiogenesis. These coordinated cellular and molecular changes translated into substantial functional recovery, evidenced by restored epicardial electrical propagation, improved electromechanical coupling, and a significant increase in cardiac function. Our findings demonstrate that this ANN\u2010optimized, adhesive\u2010electrocoupling hydrogel provides a comprehensive and synergistic solution for repairing the infarcted heart.\n                  <\/jats:p>","DOI":"10.1002\/adma.74540","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:12:18Z","timestamp":1786180338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pseudocapacitive Charge\u2010Driven Adhesive\u2010Electrocoupling Hydrogels for Myocardial Infarction Repair via Interstitial Microenvironment Remodeling"],"prefix":"10.1002","volume":"38","author":[{"given":"Shengxi","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Neurology Institute of Neuroscience The Second Affiliated Hospital Guangzhou Medical University  Guangzhou China"},{"name":"Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University  Chengdu 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