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Targeting succinate thus represents a pivotal strategy to reestablish metabolic equilibrium. Here, through biomimetic electronic structure engineering, we report an atomically precise Pt\n                    <jats:sub>3<\/jats:sub>\n                    Cu\n                    <jats:sub>2<\/jats:sub>\n                    cluster engineered with intrinsic succinate dehydrogenase (SDH)\u2010mimicking activity that catalyzes succinate oxidation to restore energy metabolism. The Pt\n                    <jats:sub>3<\/jats:sub>\n                    Cu\n                    <jats:sub>2<\/jats:sub>\n                    cluster exhibits a succinate\u2010binding affinity 4.52\u2010fold superior to that of native SDH, wherein the Pt\u2500Cu dual\u2010metal active center structurally and functionally recapitulates the Fe\u2500S catalytic motifs of SDH, enabling precise substrate recognition and efficient electron transfer. In disease models of energy metabolic dysfunction, Pt\n                    <jats:sub>3<\/jats:sub>\n                    Cu\n                    <jats:sub>2<\/jats:sub>\n                    reduces succinate accumulation by 43.54% and restores ATP production by 5.31\u2010fold, effectively rescuing hepatic energy metabolic dysfunction. Concurrently, it decreases lipid accumulation by 79.82% and resolves hepatic inflammation through normalization of the PI3K\/Akt signaling axis. Beyond the liver, systemic normalization of succinate and inflammatory cytokines attenuates neuroinflammation, restores cerebral energy supply, and improves cognitive function. This work establishes atomically precise metal nanoclusters as a compelling enzyme\u2010mimetic strategy for targeting metabolic\u2010inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/adma.74550","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:09:09Z","timestamp":1786180149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atomically Precise Pt\n                    <sub>3<\/sub>\n                    Cu\n                    <sub>2<\/sub>\n                    Clusters Restore Energy Metabolism via Targeted Succinate Degradation"],"prefix":"10.1002","volume":"38","author":[{"given":"Fangzhen","family":"Tian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Medical Materials and Devices Academy of Medical Engineering and Translational Medicine Tianjin University  Tianjin 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