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Although RNA interference (RNAi) holds promise for IPF treatment, current delivery systems are hampered by complex preparation, redundant components, and an inability to modulate oxidative stress, which severely compromises their therapeutic outcomes. Herein, we design a single\u2010component, lung\u2010targeted nanosystem, PPN@siIL11, that simplifies formulation while integrating dual functions of efficient siRNA delivery and reactive oxygen species (ROS) scavenging. Upon intravenous administration, this streamlined platform exhibits enhanced pulmonary accumulation, effectively silences the profibrotic gene IL11, and suppresses fibroblast\u2010to\u2010myofibroblast transdifferentiation and excessive extracellular matrix deposition. Concurrently, it scavenges overproduced ROS to alleviate oxidative stress\u2013mediated lung damage. Both in vitro and in vivo results demonstrate the potent anti\u2010fibrotic efficacy of PPN@siIL11. By overcoming critical drawbacks of conventional multi\u2010component carriers, this multifunctional single\u2010component platform establishes a translatable approach for RNAi\u2010based IPF therapy, with potential applicability to other lung diseases.<\/jats:p>","DOI":"10.1002\/adma.74615","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:01:51Z","timestamp":1787140911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["ROS\u2010Scavenging Single\u2010Component Polymeric Nanocarriers for Precision siRNA Delivery in Pulmonary Fibrosis Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuxin","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Fine Chemicals Frontiers Science Center For Smart Materials Oriented Chemical Engineering Dalian University of Technology  Dalian 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