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A central challenge is simultaneously maintaining solid\u2013solid charge transport, hydration\u2010dependent ionic conduction, and biofluid resistance within a lightweight, fixture\u2010free architecture. Here, we report a vapor\u2010fed electrochemical materials architecture for skin\u2010conformal oxygen delivery. The system integrates a mechanically interlocking 3D current collector\/catalyst interface to stabilize electronic transport, femtosecond\u2010laser\u2010defined microchannels to reconstruct vapor\u2010phase mass transport within an all\u2010solid\u2010state membrane electrode assembly, and a phase\u2010selective porous barrier blocking exudate intrusion while preserving gas diffusion. This hierarchical design enables an ultralight (&lt;4\u00a0g) patch to operate at high current densities (&gt;100\u00a0mA cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ), sustaining continuous operation for 735\u00a0h to deliver 16.8\u00a0L of high\u2010purity (&gt;99%) O\n                    <jats:sub>2<\/jats:sub>\n                    . The architecture remains stable for &gt;500\u00a0h in simulated exudates and supports efficient transdermal oxygen transport across porcine skin. In a rat pressure\u2013ulcer model, short\u2010course treatment accelerates early wound closure 1.7\u2010fold at day 3, enhancing M2 macrophage polarization and vascular normalization. These results establish a materials framework for translating wearable bioelectronics from passive information interfaces to active molecular\u2010delivery systems.\n                  <\/jats:p>","DOI":"10.1002\/adma.74636","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:32:41Z","timestamp":1786969961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Wearable Electrochemical Patch for Sustained Local Oxygen Therapy of Chronic Wounds"],"prefix":"10.1002","volume":"38","author":[{"given":"Jichen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Dermatology Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei Anhui P. R. 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