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Here, we report a thermoreversible gelatin\u2010based gel that transitions from a flowable precursor to a conformal conductive interface layer upon cooling, enabling both in situ formation on skin and use as a preformed compliant interlayer between metal electrodes and neural tissue. The gel integrates a uniformly dispersed carbon nanotube network with mobile ions from sodium chloride to support coexisting ionic and electronic transport pathways, while the gelatin\u2010based matrix provides moisture retention and mechanical compliance. It achieves low interface impedance on hairless and hairy skin, outperforming commercial electrocardiogram gels, and electroencephalogram pastes. The gel's versatility is demonstrated across multiple modalities and species, including electrocardiography and acute peripheral nerve stimulation in rats, compound muscle action potential and sensory nerve action potential recordings in rhesus monkeys, and electroencephalography in humans. Beyond these cross\u2010sectional assessments, repeated short\u2010term recordings using the gel enable longitudinal evaluation of peripheral nerve functional recovery in nerve injury models. Together, this work establishes a tissue\u2010adaptive and reconfigurable strategy for achieving stable, low\u2010impedance bioelectronic interfacing across complex biological environments.<\/jats:p>","DOI":"10.1002\/adma.74724","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:15:07Z","timestamp":1787224507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conformal Thermoreversible Gelatin\u2010Based Gel for High\u2010Fidelity Electrophysiological Recording and Acute Peripheral Nerve Interfacing"],"prefix":"10.1002","volume":"38","author":[{"given":"Ruinan","family":"Hao","sequence":"first","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing P. R. China"},{"name":"State Key Laboratory of Organic\u2010Inorganic Composites Beijing University of Chemical Technology  Beijing P. R. 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