{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:57:59Z","timestamp":1792166279720,"version":"4.4.0"},"reference-count":44,"publisher":"Wiley","issue":"58","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025B1515120011"],"award-info":[{"award-number":["2025B1515120011"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012036"],"award-info":[{"award-number":["2025A1515012036"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52433010"],"award-info":[{"award-number":["52433010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473129"],"award-info":[{"award-number":["52473129"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Current therapies for inflammatory skin diseases predominantly rely on broad systemic immunosuppression and lack precision toward defined immune\u2010cell subsets. Here, we identify CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    nonclassical monocytes (NCMs) as an inflammatory monocyte subset that contributes to the amplification of psoriasiform inflammation, as supported by integrated analyses of human single\u2010cell transcriptomics, genetic depletion, and adoptive\u2010transfer models. To preferentially engage these disease\u2010associated NCMs, we engineer an artificial cell\u2013microneedle platform, termed CX3@GUV\u2010DMF, comprising CX3CL1\u2010functionalized, drug\u2010loaded giant unilamellar vesicles (GUVs) embedded within a dissolvable hyaluronic acid (HA) microneedle array. Following intradermal insertion, surface\u2010presented CX3CL1 actively navigates GUVs to pathogenic CX3CR1\n                    <jats:sup>+<\/jats:sup>\n                    NCMs, facilitating the targeted, sustained release of the loaded drug. In vivo evaluations and transcriptomic profiling demonstrate that this localized immunomodulatory strategy attenuates inflammatory myeloid activation, neutrophil infiltration, and Th17\u2010associated responses while promoting restoration of epidermal barrier\u2010associated programs. These findings establish a materials\u2010enabled strategy for subset\u2010oriented immune modulation and local inflammatory\u2010niche remodeling, advancing inflammatory skin therapy beyond nonspecific immunosuppression.\n                  <\/jats:p>","DOI":"10.1002\/adma.74726","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:36:42Z","timestamp":1787294202000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Nonclassical Monocytes via Artificial Cell\u2010Microneedles for Precision Psoriasis Therapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Qian","family":"Chen","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou P. R. China"},{"name":"Key Laboratory of Biomedical Materials of the Ministry of Education South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Sun","sequence":"additional","affiliation":[{"name":"Medical Faculty Heidelberg, Centre for Paediatric and Adolescent Medicine, Department I, Division of Paediatric Neurology and Metabolic Medicine Heidelberg University  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-4155","authenticated-orcid":false,"given":"Hantao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Zhujiang Hospital Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Mai","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-0185","authenticated-orcid":false,"given":"Yong","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Qin","sequence":"additional","affiliation":[{"name":"Medical Devices Research &amp; Testing Center South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9590-1671","authenticated-orcid":false,"given":"Xunru","family":"Liang","sequence":"additional","affiliation":[{"name":"Medical Devices Research &amp; Testing Center South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nanfang Hospital of Southern Medical University  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6863-6016","authenticated-orcid":false,"given":"Pengchao","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou P. R. China"},{"name":"Key Laboratory of Biomedical Materials of the Ministry of Education South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-0918","authenticated-orcid":false,"given":"Liming","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology  Guangzhou P. R. China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction South China University of Technology  Guangzhou P. R. China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering South China University of Technology  Guangzhou P. R. China"},{"name":"Key Laboratory of Biomedical Materials of the Ministry of Education South China University of Technology  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(21)00184\u20107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg6007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba6500"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010024\u201008991\u20107"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.030791"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010023\u201001445\u20104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010042617\u2010053119"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.03.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.03.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat5005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500242"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202500303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2cs00999d"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan4665"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2004.11.003"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.06.016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02052"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(89)70071\u20102"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2021.100040"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002345\u2010x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010023\u201001205\u20103"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001329\u20102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010023\u201001375\u20101"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard\u20102023\u2010225433"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.964274"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1040775"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac9407"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2063"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal4508"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202524002"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010024\u201001078\u20106"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.013"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.09.008"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304582"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202418352"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717541003667798"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406153"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010021\u201000720\u20101"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.03.004"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010020\u201002048\u20106"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.021"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202345"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002351\u2010z"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.71"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74726","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:42:42Z","timestamp":1792165362000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":44,"journal-issue":{"issue":"58","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.74726"],"URL":"https:\/\/doi.org\/10.1002\/adma.74726","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,20]]},"assertion":[{"value":"2026-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74726"}}