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However, conventional supramolecular co\u2010assembly typically necessitates stoichiometric or excess guest loading to achieve effective chirality transfer, a requirement that often compromises structural fidelity and chiroptical efficiency due to inefficient stereochemical communication. Here, we report a sub\u2010stoichiometric co\u2010assembly strategy wherein trace amounts of an achiral modulator (berberine, BBR) cooperatively intercalate within a chiral supramolecular framework (LPF\/DPF; left\u2010\/right\u2010handed phenylalanine\u2010based gelators) to induce potent chiroptical amplification. We demonstrate that a minimal guest\u2010to\u2010host mole ratio of 0.2 is sufficient to capture and amplify host chirality, yielding luminescence dissymmetry factors (|\n                    <jats:italic>g<\/jats:italic>\n                    <jats:sub>lum<\/jats:sub>\n                    | \u2248 0.08) an order of magnitude higher than those produced by stoichiometric equivalents. Mechanistic investigations reveal that sparse intercalation at this sub\u2010stoichiometric threshold preserves the underlying hydrogen\u2010bonded network while enforcing a precise helical registry through synergistic \u03c0\u2013\u03c0 and electrostatic interactions that ensures thermodynamic stability (\u0394\n                    <jats:italic>G<\/jats:italic>\n                    \u00b0). While stoichiometric excess results in kinetically trapped, non\u2010helical aggregates, this sub\u2010stoichiometric control establishes a robust design principle for translating molecular\u2010scale interactions into high\u2010performance chiroptical materials with minimal guest loading.\n                  <\/jats:p>","DOI":"10.1002\/adma.74767","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T16:05:06Z","timestamp":1787414706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sub\u2010Stoichiometric Supramolecular Co\u2010Assembly Strategy Enabling Efficient Chirality Transfer and CPL Amplification"],"prefix":"10.1002","author":[{"given":"Sravan","family":"Baddi","sequence":"first","affiliation":[{"name":"State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Key Laboratory For Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1770-8947","authenticated-orcid":false,"given":"Fengli","family":"Gao","sequence":"additional","affiliation":[{"name":"State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Key Laboratory For Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  Shanghai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1350-8682","authenticated-orcid":false,"given":"Changli","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Lab of Metal Matrix Composites School of Materials Science and Engineering Shanghai Key Laboratory For Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University  Shanghai P. R. 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