{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:43:50Z","timestamp":1792680230652,"version":"4.5.0"},"reference-count":65,"publisher":"Wiley","issue":"59","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 52572299"],"award-info":[{"award-number":["NSFC 52572299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52272273"],"award-info":[{"award-number":["52272273"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20347"],"award-info":[{"award-number":["U22A20347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pyroelectric dynamic therapy is capable of triggering pro\u2010inflammatory cell death and anti\u2010tumor trained immunity. However, the high thermal conductivity, quick pyroelectric carrier recombination of traditional pyroelectric materials, and the limited immunogenicity of tumor cells greatly hinder the efficacy of trained immunotherapy. Herein, a nanoplatform integrating iron\u2010doped defect\u2010engineered misfit layered calcium cobalt oxide (Ca\n                    <jats:sub>3<\/jats:sub>\n                    Co\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>9\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    ) nanostructure, immune adjuvant polyinosinic\u2010polycytidylic acid, and nanovesicles extracted from 4T1 cells is constructed to initiate pyroptosis and the anti\u2010tumor trained immunotherapy. The low thermal conductivity of misfit layered Ca\n                    <jats:sub>3<\/jats:sub>\n                    Co\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>9\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    reduces the overall thermal conductivity. The oxygen vacancies created by defect engineering serve as electron traps, inhibiting charge carrier recombination. Therefore, Ca\n                    <jats:sub>3<\/jats:sub>\n                    Co\n                    <jats:sub>4<\/jats:sub>\n                    O\n                    <jats:sub>9\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>x<\/jats:sub>\n                    <\/jats:italic>\n                    achieves multi\u2010level energy conversion between thermal, electrical, and chemical fields, enriching various reactive oxygen species (ROS). Polyinosinic\u2010polycytidylic acid synergizing with ROS activates caspase\u20101\/Gasdermin D\u2010mediated pyroptosis, and stimulates the secretion of more types of inflammatory cytokines through the stimulator of interferon genes (STING) pathway, leveraging the limited immunogenicity of the tumor environment. Nanovesicles provide precisely homologous tumor\u2010targeting ability by efficient biomimetic fusion. The nanoplatform demonstrates excellent pyroptosis\u2010inducing efficiency and anti\u2010tumor immunity training ability, indicating the feasibility of the multi\u2010physical field energy conversion and defect engineering strategy for synergistic enhancement of pyroelectric dynamic therapy in anti\u2010tumor trained immunotherapy.\n                  <\/jats:p>","DOI":"10.1002\/adma.74768","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:30:21Z","timestamp":1787643021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Defect Engineered Pyroelectric Ca\n                    <sub>3<\/sub>\n                    Co\n                    <sub>4<\/sub>\n                    O\n                    <sub>9\u2212<\/sub>\n                    <i>\n                      <sub>x<\/sub>\n                    <\/i>\n                    Nanostructure Enables Pyroptosis and Trained Immunotherapy"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuxuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering The Hong Kong Polytechnic University  Kowloon Hong Kong SAR P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wubin","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Sixth Affiliated Hospital of Harbin Medical University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2371-5119","authenticated-orcid":false,"given":"He","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"},{"name":"Yangtze Delta Region Advanced Research Institute of Harbin Engineering University Harbin Engineering University  Nantong P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-1803","authenticated-orcid":false,"given":"Piaoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Superlight Materials and Surface Technology Ministry of Education College of Materials Science and Chemical Engineering Harbin Engineering University  Harbin P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002225\u2010w"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abq7248"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001535\u20108"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001578\u2010x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571\u2010024\u201000908\u20109"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010025\u201001132\u2010x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.06.010"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408685"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41377\u2010025\u201001757\u20106"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202414697"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010024\u201001545\u20106"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202507186"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202410536"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401384"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CS01095C"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202402806"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216282"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202302360"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202405929"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202314249"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202400756"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202401111"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202419376"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202505784"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c16281"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055529\u20108"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joule.2024.09.009"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevX.15.011063"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043692\u20103"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2023.108184"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307038"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202308726"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409245"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2024.109480"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414422"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202423055"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202409259"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.202202999"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2023.113186"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409201"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202504352"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202414738"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2019.07.003"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40145\u2010020\u20100413\u20106"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/aenm.202400676"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202509925"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202412069"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS01007H"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304322"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408906"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202507363"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202411030"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006007"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508941"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313086"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202414432"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2025.110929"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419984"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00507D"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010024\u201000781\u20109"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538\u20107445.Am2025\u20102993"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201054862\u20102"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001786\u2010z"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312588"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74768","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74768","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:20:02Z","timestamp":1792678802000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":65,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.74768"],"URL":"https:\/\/doi.org\/10.1002\/adma.74768","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"2026-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74768"}}