{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:26:53Z","timestamp":1787390813771,"version":"build-2736575974"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92068119"],"award-info":[{"award-number":["92068119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52302350"],"award-info":[{"award-number":["52302350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Osteoarthritis (OA) is a multifactorial degenerative joint disease characterized by irreversible cartilage deterioration associated with chronic inflammation, oxidative stress, tissue acidosis, and abnormal mechanical loading. During OA progression, inflammation\u2010associated metabolic reprogramming and hypoxia\u2010enhanced glycolysis promote lactate accumulation and local acidosis. OA\u2010associated acidosis may function as an exacerbating factor within this pathological microenvironment by engaging acid\u2010sensing pathways and contributing to chondrocyte senescence, apoptosis, and SASP\u2010associated inflammatory amplification, thereby exacerbating cartilage degeneration. Accordingly, therapeutic strategies that actively neutralize pathological acidity while concurrently modulating inflammatory and oxidative stress cascades may provide a more robust, disease\u2010modifying approach for OA intervention. Herein, we designed a nanoreactor termed OLDH\u2010DP@POM by integrating mildly alkaline layered double hydroxide (LDH) nanosheets with active acid\u2010neutralizing capability and anchoring polyoxometalates (POM) with antioxidant activity, thereby enabling coordinated regulation of pathological acidosis and oxidative stress. Meanwhile, lubrication\u2010enhancing zwitterionic poly(2\u2010methacryloyloxyethyl phosphorylcholine) (PMPC) polymer brushes were grafted, endowing the nanoreactor with superior joint lubrication and chondroprotective capability. Both in vitro and in vivo results demonstrated that OLDH\u2010DP@POM effectively neutralized local acidosis at osteoarthritic lesions, substantially ameliorated synovial inflammation, suppressed Piezo\u2010mediated mechanotransduction, delayed chondrocyte senescence, and ultimately attenuated cartilage degeneration. Overall, this work provides a promising nanotherapeutic platform for disease\u2010modifying treatment of OA.<\/jats:p>","DOI":"10.1002\/adma.74772","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T09:01:31Z","timestamp":1787389291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Acid\u2010Neutralizing Nanoreactor Counteracts Senescence\u2010Driven Cartilage Degeneration in Osteoarthritis"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6589-8923","authenticated-orcid":false,"given":"Yingying","family":"Liu","sequence":"first","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9455-474X","authenticated-orcid":false,"given":"Chuandong","family":"Qin","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"},{"name":"National Center For Orthopaedics Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1309-696X","authenticated-orcid":false,"given":"Yongkang","family":"Xian","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-6055","authenticated-orcid":false,"given":"Yajun","family":"Liu","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"},{"name":"National Center For Orthopaedics Beijing Research Institute of Traumatology and Orthopedics, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9507-1500","authenticated-orcid":false,"given":"Ziliang","family":"Dong","sequence":"additional","affiliation":[{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-3113","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Light Industry State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology (Shandong Academy of Sciences)  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-0559","authenticated-orcid":false,"given":"Shuping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Biomedical Sciences College &amp; Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 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