{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:44:47Z","timestamp":1792680287275,"version":"4.5.0"},"reference-count":57,"publisher":"Wiley","issue":"59","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0715700"],"award-info":[{"award-number":["2021YFA0715700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFE0202201"],"award-info":[{"award-number":["2018YFE0202201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22293044"],"award-info":[{"award-number":["22293044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51732011"],"award-info":[{"award-number":["51732011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22222508"],"award-info":[{"award-number":["22222508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21975241"],"award-info":[{"award-number":["21975241"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22475192"],"award-info":[{"award-number":["22475192"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22305240"],"award-info":[{"award-number":["22305240"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK2340000112"],"award-info":[{"award-number":["WK2340000112"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["WK9110000143"],"award-info":[{"award-number":["WK9110000143"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["QK26E020004"],"award-info":[{"award-number":["QK26E020004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Emergency hemostasis during prehospital care significantly reduces trauma\u2010related mortality. Nanoclay exhibits potent procoagulant properties, but its detachment from the substrate leads to non\u2010negligible adverse reactions and diminished hemostatic efficiency, hindering its clinical application. Despite improved immobilization via polymer incorporation, irreversible surface encapsulation undermines the procoagulant efficacy of nanoclays. Here, inspired by the anchoring mechanism of fish scales to skin via collagen fibers, we introduce a nanofiber\u2010bridged design that enables robust immobilization of nanoclay and maximized loading density, while also achieving its full exposure for optimal hemostatic performance. The microfiber\u2010derived nanofiber network expands the interfacial contact area and anchors nanosheet inner surfaces via synergistic covalent and non\u2010covalent interactions, effectively redistributing stress to resist dynamic shear forces. The resulting kaolin\u2010cotton hemostatic dressing demonstrates superior physical stability (no detectable kaolin leakage) and enhanced hemostatic efficacy in rat (62%), rabbit (58%), and pig (35%\u201343%) hemorrhage models compared with conventional hemostatic agents. Importantly, no leakage\u2010induced chronic inflammation was observed. Moreover, laboratory\u2010scale preparation and processing of 5\u00a0kg products demonstrate the feasibility of industrial\u2010scale production, making them further processable into various cotton\u2010based materials. This bioinspired dressing offers improved efficacy and safety, along with affordability, underscoring its potential for clinical translation.<\/jats:p>","DOI":"10.1002\/adma.74776","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:23:18Z","timestamp":1787746998000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinspired Hemostatic Dressings for Rapid and Safe Bleeding Control Via Nanofiber Bridging of Kaolin and Cotton"],"prefix":"10.1002","volume":"38","author":[{"given":"Guang\u2010Zhen","family":"Wang","sequence":"first","affiliation":[{"name":"New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials &amp; Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials &amp; Chemistry Hefei National Research Center for Physical Sciences At the Microscale University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Orthopedics Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8908-1967","authenticated-orcid":false,"given":"Huai\u2010Ling","family":"Gao","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao\u2010Xue","family":"Guo","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials &amp; Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials &amp; Chemistry Hefei National Research Center for Physical Sciences At the Microscale University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Nian","family":"Yang","sequence":"additional","affiliation":[{"name":"College &amp; Hospital of Stomatology Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6187-716X","authenticated-orcid":false,"given":"Fang\u2010Tao","family":"Ruan","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials &amp; Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials &amp; Chemistry Hefei National Research Center for Physical Sciences At the Microscale University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-1815","authenticated-orcid":false,"given":"Qi\u2010Chun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Division of Life Sciences and Medicine The First Affiliated Hospital of USTC University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Fu","family":"Chen","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials &amp; Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials &amp; Chemistry Hefei National Research Center for Physical Sciences At the Microscale University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9677-901X","authenticated-orcid":false,"given":"Liang","family":"Dong","sequence":"additional","affiliation":[{"name":"Hangzhou Institute of Medicine Chinese Academy of Sciences Zhejiang Cancer Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-1011","authenticated-orcid":false,"given":"Shu\u2010Hong","family":"Yu","sequence":"additional","affiliation":[{"name":"New Cornerstone Science Laboratory Department of Chemistry Institute of Biomimetic Materials &amp; Chemistry Anhui Engineering Laboratory of Biomimetic Materials Division of Nanomaterials &amp; Chemistry Hefei National Research Center for Physical Sciences At the Microscale University of Science and Technology of China  Hefei China"},{"name":"Institute of Innovative Materials Department of Chemistry Department of Materials Science and Engineering Shenzhen Key Laboratory of Sustainable Biomimetic Materials Guangdong Provincial Key Laboratory of Biomimetic Materials and Green Energy Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61224\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra067742"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010383"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032803\u20101"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1406979111"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02523F"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adi4490"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006756"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028209\u20108"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c01015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900764"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000397"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja061717a"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3BM01326J"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201900332"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181c3bcca"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.7205\/MILMED.169.9.716"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009849\u20109"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41570\u2010021\u201000323\u2010z"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201026237\u20104"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202265"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwac162"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309485"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201700859"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201704452"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000951"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2021.132049"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123357"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124148"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.05.140"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.05.035"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118155"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c01370"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300672"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2024.213932"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41929\u2010021\u201000654\u20106"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.7"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010022\u201001384\u20101"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsolstr.2013.10.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2231"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scirobotics.abd2823"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aat7223"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211099"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaa230"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12392"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202002182"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adx4556"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508606"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202408458"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035907\u20104"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010019\u20100099\u2010y"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf9635"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.27.282"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/app10238681"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj8331"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2903"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74776","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74776","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74776","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:20:25Z","timestamp":1792678825000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":57,"journal-issue":{"issue":"59","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/adma.74776"],"URL":"https:\/\/doi.org\/10.1002\/adma.74776","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2026-01-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74776"}}