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We introduce glycogen as a nutritional nanoparticle that provides cell\u2010mediated, autonomous nutrient release to support long\u2010term survival under extreme metabolic stress. We demonstrate that human mesenchymal stromal cells (hMSCs) survive for weeks in anoxia and serum deprivation when provided extracellular glycogen. Contrary to long\u2010held assumptions, hMSCs secrete glycogen\u2010degrading enzymes, enabling cell\u2010density\u2010controlled extracellular glycogenolysis and sustained release of glucose and metabolic intermediates, positioning glycogen as the first\u2010of\u2010its\u2010kind metabolic battery. This cell\u2010responsive process maintains metabolic activity, limits glycolytic acidosis, and enhances pro\u2010angiogenic signaling. To translate this mechanism into a versatile materials platform, we engineered core\u2010shell dextran\u2010tyramine microcapsules that stably encapsulate glycogen while permitting diffusion of enzymes and degradation products. Integrated into centimeter\u2010scale GelMA constructs, these microcapsules maintained hMSC viability and function for at least 1 month under anoxia. In vivo, glycogen\u2010loaded implants promote deep cellular infiltration, enhanced matrix remodeling, increased M2 macrophage polarization, and orchestrated accelerated vascularization. This work establishes the novel concept of glycogen\u2010based nutritional nanoparticles as metabolic batteries to endow engineered tissues with autonomous self\u2010feeding capacity, enabling scalable and functional living materials for regenerative medicine and related technologies.<\/jats:p>","DOI":"10.1002\/adma.74812","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:47:33Z","timestamp":1788248853000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Self\u2010Feeding Living Materials Enabled by Cell Responsive Glycogen Nanoparticles as Metabolic Batteries"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-3875","authenticated-orcid":false,"given":"Melvin","family":"Gurian","sequence":"first","affiliation":[{"name":"Faculty of Science and Technology Department of BioEngineering Technologies Leijten Laboratory TechMed Centre University of Twente  Enschede the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-3313","authenticated-orcid":false,"given":"Niels G. 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