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Their anisotropic shape has proven advantageous in the fabrication of granular hydrogels and microporous annealed particle scaffolds (MAPs), featuring larger pore sizes in comparison to their spherical counterparts. However, to enable the use of rod\u2010shaped microgels as building blocks for high\u2010throughput tissue models, a robust and scalable production method is needed. Here, we report a microfluidic fabrication method to produce rod\u2010shaped microgels by combining step\u2010emulsification (SE) and droplet confinement. We highlight the development of the microfluidic chip design, and characterize the properties of the microgel rods produced via on\u2010chip gelation, using two light\u2010induced polymerization chemistries. Compared to single\u2010channel microfluidic techniques, rod\u2010shaped microgels are generated in eight parallelized microchannels in a relevant size range for tissue engineering applications, holding potential for further upscaling.<\/jats:p>","DOI":"10.1002\/adma.74822","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:51:22Z","timestamp":1787975482000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Upscaling the Fabrication of Rod\u2010Shaped Microgels: A Microfluidic Method Combining Step\u2010Emulsification With Consecutive Droplet Confinement in Parallelized Microchannels"],"prefix":"10.1002","volume":"38","author":[{"given":"Matthias","family":"Mork","sequence":"first","affiliation":[{"name":"Institute for Technical and Macromolecular Chemistry (ITMC) Chair of Macromolecular Materials for Medicine RWTH Aachen University  Aachen Germany"},{"name":"DWI\u2014Leibniz Institute for Interactive Materials e. 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Aachen Germany"},{"name":"Department of Advanced Materials For Biomedicine (AMB) CBMS\u2014Center For Biohybrid Medical Systems AME\u2014Institute of Applied Medical Engineering University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Romahn","sequence":"additional","affiliation":[{"name":"Institute for Technical and Macromolecular Chemistry (ITMC) Chair of Macromolecular Materials for Medicine RWTH Aachen University  Aachen Germany"},{"name":"DWI\u2014Leibniz Institute for Interactive Materials e. V.  Aachen Germany"},{"name":"Department of Advanced Materials For Biomedicine (AMB) CBMS\u2014Center For Biohybrid Medical Systems AME\u2014Institute of Applied Medical Engineering University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Klasen","sequence":"additional","affiliation":[{"name":"Institute for Technical and Macromolecular Chemistry (ITMC) Chair of Macromolecular Materials for Medicine RWTH Aachen University  Aachen Germany"},{"name":"DWI\u2014Leibniz Institute for Interactive Materials e. V.  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Bergerbit","sequence":"additional","affiliation":[{"name":"DWI\u2014Leibniz Institute for Interactive Materials e. V.  Aachen Germany"},{"name":"Department of Advanced Materials For Biomedicine (AMB) CBMS\u2014Center For Biohybrid Medical Systems AME\u2014Institute of Applied Medical Engineering University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-0977","authenticated-orcid":false,"given":"Laura","family":"De Laporte","sequence":"additional","affiliation":[{"name":"Institute for Technical and Macromolecular Chemistry (ITMC) Chair of Macromolecular Materials for Medicine RWTH Aachen University  Aachen Germany"},{"name":"DWI\u2014Leibniz Institute for Interactive Materials e. V.  Aachen Germany"},{"name":"Department of Advanced Materials For Biomedicine (AMB) CBMS\u2014Center For Biohybrid Medical Systems AME\u2014Institute of Applied Medical Engineering University Hospital RWTH Aachen Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr000108x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214804"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3839"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4294"},{"key":"e_1_2_8_6_1","first-page":"1","article-title":"Functionalized microgel rod s interlinked into soft macroporous structures for 3D cell culture","volume":"9","author":"Rommel D.","year":"2022","journal-title":"Advancement of Science"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109194"},{"key":"e_1_2_8_8_1","first-page":"1","article-title":"Annealing high Aspect Ratio Microgels Into Macroporous 3D Scaffolds Allows for Higher Porosities and Effective Cell Migration","volume":"11","author":"Suturin A. 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