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The development of tissue engineering scaffolds mimicking these three parts of bone tissue and enabling synergistic functional performance remains a significant challenge. Herein, a biomimetic periosteum\u2010bone integrated scaffold was successfully fabricated by assembling the outer engineered periosteum with the inner Haversian bone module, achieving structural and functional biomimicry of natural bone tissue. The engineered periosteum constructed with periosteal cells (PCs) with zinc silicate nanorods (ZS) spontaneously recapitulated the diverse bioactivities of natural periosteum, thus facilitating the synergistic osteogenesis when co\u2010cultured with bone marrow related cells in vitro. Coarse\u2011grained molecular dynamics simulations revealed that surface curvature of ZS affected membrane bending\u2010energy landscape and particle reorientation during endocytosis, thereby regulating PCs\u2019 function via altered intracellular ion accumulation kinetics. Notably, in a segmental bone defect, the engineered periosteum and Haversian\u2010bone module exhibited the superior synergistic effect on integrative bone regeneration in vivo. More importantly, the engineered periosteum was found to functionally replace natural periosteum with the mechanism of ZS activating a specific fibrogenic sub\u2010cluster with potent chondrogenesis and neurovascular communication. This biomimetic periosteum\u2010bone integrated scaffold offers a fresh perspective for the design of full structure and function\u2010mimicking bone tissue engineering materials.<\/jats:p>","DOI":"10.1002\/adma.74879","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:45:09Z","timestamp":1788183909000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioprinting of Biomimetic Periosteum\u2010Bone Integrated Scaffolds"],"prefix":"10.1002","author":[{"given":"Lin","family":"Du","sequence":"first","affiliation":[{"name":"State Key Laboratory of High Performance Ceramics Shanghai Institute of Ceramics Chinese Academy of Sciences  Shanghai China"},{"name":"Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences  Beijing 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