{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:06:36Z","timestamp":1789103196706,"version":"build-2803163510"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22665017"],"award-info":[{"award-number":["22665017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52073077"],"award-info":[{"award-number":["52073077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22065011"],"award-info":[{"award-number":["22065011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glioblastoma (GBM) therapy remains limited by poor blood\u2013brain barrier (BBB) penetration and an adaptive, immunosuppressive tumor microenvironment (TME). Here, we engineer multifunctional FeWO\n                    <jats:sub>x<\/jats:sub>\n                    @Ag\/Bi\n                    <jats:sub>2<\/jats:sub>\n                    Te\n                    <jats:sub>3<\/jats:sub>\n                    \u2010HA nanozymes (FABH) to integrate magneto\u2010pyroelectric dynamic therapy (MPEDT), metabolic regulation, immune activation, and near\u2010infrared II fluorescence imaging. Under alternating magnetic field (AMF) stimulation, the Ag\/Bi\n                    <jats:sub>2<\/jats:sub>\n                    Te\n                    <jats:sub>3\u2013<\/jats:sub>\n                    FeWO\n                    <jats:sub>x<\/jats:sub>\n                    S\u2010scheme heterojunction promotes pyroelectric charge separation and reactive oxygen species (ROS) generation, thereby strengthening MPEDT and inducing immunogenic cell death. FABH nanozymes also show AMF\u2010enhanced L\u2010cysteine oxidase (LCO), reduced nicotinamide adenine dinucleotide (NADH) oxidase (NOX), lactate oxidase (LOX), and xanthine oxidoreductase (XOR) activities. These cascaded activities deplete glutathione, improve oxygen availability, block protective autophagy, and remodel lactate\u2010 and urate\u2010associated metabolism to activate innate and adaptive antitumor immunity. Magnetic guidance further enables FABH nanozymes to cross the BBB and accumulate in deep GBM lesions, while silver ion incorporation improves thermoelectric performance and supports real\u2010time NIR\u2010II imaging. This integrated strategy promotes GBM ablation through BBB penetration, ROS storm generation, autophagy blockade, and immunometabolic remodeling.\n                  <\/jats:p>","DOI":"10.1002\/adma.74888","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:29:16Z","timestamp":1789100956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An \"AND\" Logic Gate S\u2010Scheme Nanozyme for Magneto\u2010Pyroelectric Dynamic Therapy Integrated With Lactate\u2013Urate Immunometabolic Remodeling in Glioblastoma"],"prefix":"10.1002","author":[{"given":"Ruocan","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"},{"name":"School of Life and Health Sciences Collaborative Innovation Center of Life and Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundi","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"},{"name":"Engineering Research Center For Hainan Biological Sample Resources of Major Diseases Key Laboratory of Emergency and Trauma of Ministry of Education The First Affiliated Hospital Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanran","family":"Qu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Life and Health Sciences Collaborative Innovation Center of Life and Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyang","family":"Shao","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Engineering Research Center For Hainan Biological Sample Resources of Major Diseases Key Laboratory of Emergency and Trauma of Ministry of Education The First Affiliated Hospital Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5689-538X","authenticated-orcid":false,"given":"Xilong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Digital Medical Engineering School of Biomedical Engineering The Affiliated Sanya Central Hospital of Hainan University School of Pharmaceutical Sciences Hainan University  Sanya China"},{"name":"Hainan Engineering Research Center for Drug Screening and Evaluation Key Laboratory of Tropical Biological Resources of Ministry of Education Collaborative Innovation Center of One Health Hainan University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202516990"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100226\u20105"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2024.102295"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018\u2010025\u201000985\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201054382\u2010z"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.141737"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100673"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201066657\u20100"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.173045"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202506400"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.26599\/NR.2025.94908256"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.216674"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010024\u201002041\u20105"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2026.112585"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202520859"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2025.217132"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201057672\u20102"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202400416"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.161353"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.75094"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2MH01221A"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.0c00039"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.010"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010025\u201001347\u20101"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202512230"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113005"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010025\u201001839\u2010y"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c02005"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010022\u201001762\u20106"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.2016159"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001733\u2010y"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157763"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.146428"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4TA03432E"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202002753"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c10663"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics12010033"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202407453"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.1c04005"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.5c00017"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2025.117555"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202501617"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18732"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2022.101374"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jallcom.2026.187136"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202210098"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MH00275G"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nanoen.2020.104810"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514299"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.163581"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2026.126533"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202312124"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202422203"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c20192"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025095\u20104"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202211570"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202408461"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201022865\u2010y"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2021.119930"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202409026"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.102962"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.4c04523"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122570"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122293"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903323"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001826\u20108"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.032"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.016"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202109354"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590\u2010025\u201002172\u20100"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.11.027"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.74888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.74888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:29:17Z","timestamp":1789100957000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.74888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":71,"alternative-id":["10.1002\/adma.74888"],"URL":"https:\/\/doi.org\/10.1002\/adma.74888","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"assertion":[{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e74888"}}