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We develop a heterogeneous Janus e\u2010skin enabled by gel\u2010fiber\u2010mediated interlayer adhesion and co\u2010design of materials, structure, and architecture. An engineered polyurethane ionogel (PUIL) coupled with an elastic SBS scaffold redistributes mechanical stress. Hydrogen bonding and ion\u2010dipole interactions immobilize the liquid metal (LM) conductor to form a reconfigurable interface. Consequently, interleaved conductive, strain\u2010insensitive nanofiber electrodes mitigate LM migration and leakage and exhibit exceptional long\u2010term electrical stability, withstanding 400% strain with minimal resistance change (R\/R\n                    <jats:sub>0<\/jats:sub>\n                    \u2248 1.07). The bonding interlayer and hierarchically porous Janus membrane create a surface\u2010energy gradient that promotes air permeability and unidirectional moisture transport, thereby improving comfort and cycling durability. Additionally, the Janus fibrous membrane mitigates strain\/thermal\/moisture\u2010induced signal distortion, ensuring stable bioelectrical feedback and bolstering the robustness of machine\u2010learning\u2010assisted decoding in self\u2010powered human\u2013machine interactions. Remarkably, the e\u2010skin exhibits excellent scalable bioinspired multifunctional protection, enabling seamless module integration for electromagnetic shielding and on\u2010demand thermal management. This work paves the way for next\u2010generation human\u2013machine interfaces by demonstrating a holistic strategy that achieves wearer comfort, multifunctional integration, and multi\u2010scenario AI interaction.\n                  <\/jats:p>","DOI":"10.1002\/adma.74900","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:59:43Z","timestamp":1788850783000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bio\u2010Inspired Janus All\u2010Nanofiber Self\u2010Powered Electronic Skins for Multifunctional, High\u2010Resolution, Artifact\u2010Free Human\u2013Machine Interface"],"prefix":"10.1002","author":[{"given":"Kefan","family":"Fan","sequence":"first","affiliation":[{"name":"Key Laboratory of Carbon Fiber and Functional Polymers Ministry of Education Beijing University of Chemical Technology  Beijing P.R. 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