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In this study, we introduced a \u201cplug\u2010and\u2010play\u201d nanoadjuvant system consisting of poly(lactic acid)\u2010porphyrin\u2010cobalt ion co\u2010formulated with immunostimulatory saponin QS\u201021 (PPCoQ). PPCoQ facilitated subunit vaccine assembly by coordinating antigens' polyhistidine tags with immobilized cobalt (Co\n                    <jats:sup>2+<\/jats:sup>\n                    ) within a porphyrin\u2010modified poly(lactic acid). Using the receptor\u2010binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) as a model antigen, the resulting nanovaccine, PPCoQ\u2010RBD, induced high levels of anti\u2010RBD antibodies in transgenic mice expressing human ACE2. Following viral challenge, immunized mice achieved a 99.7% clearance rate of the SARS\u2010CoV\u20102 Omicron variant, demonstrating strong humoral and cellular immune responses. Additionally, PPCoQ\u2010RBD was compatible with nebulization\u2010based inhalation, which enhanced mucosal immunity, increased IgA antibody titers, and promoted the formation of abundant tissue\u2010resident memory T cells. A model T cell epitope (OVA) was formulated to evaluate cellular responses, generating PPCoQ\u2010OVA, which significantly inhibited B16\u2010OVA tumor growth. The PPCoQ vaccine adjuvant system is easy to produce and supports efficient antigen loading, lymph node targeting, lysosomal escape, and biocompatibility, and has broad prospects for application and clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/adma.74905","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:39:46Z","timestamp":1788518386000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Poly(lactic Acid)\u2010Porphyrin\u2010Cobalt Vaccine Adjuvant System Elicits Protein\u2010 or Peptide\u2010Specific Humoral and Cellular Immunity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5895-6871","authenticated-orcid":false,"given":"Lisen","family":"Lu","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Tropical Disease Control School of Life Sciences and Medical Technology Hainan Medical University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3686-0402","authenticated-orcid":false,"given":"Deqiang","family":"Deng","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Tropical Disease Control School of Life Sciences and Medical Technology Hainan Medical University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Biomedicine and Health and College of Life Science and Technology Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Biomedicine and Health and College of Life Science and Technology Huazhong Agricultural University  Wuhan P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9052-884X","authenticated-orcid":false,"given":"Jonathan F.","family":"Lovell","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University At Buffalo State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7340-1188","authenticated-orcid":false,"given":"Muyang","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Tropical Disease Control School of Life Sciences and Medical Technology Hainan Medical University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-9539","authenticated-orcid":false,"given":"Honglin","family":"Jin","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Tropical Disease Control School of Life Sciences and Medical Technology Hainan Medical University  Haikou Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010023\u201006063\u2010y"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00262-023-03386-7","article-title":"Preliminary Clinical Study of Personalized Neoantigen Vaccine Therapy for Microsatellite Stability (MSS)\u2010Advanced Colorectal Cancer","volume":"72","author":"Yu Y. 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