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Here we report a bio\u2010hybrid assembly designed to synchronize the eradication of CRC cells and their tumor\u2010associated\n                    <jats:italic>Fusobacterium nucleatum<\/jats:italic>\n                    . This system integrates a hemoglobin (Hb)\u2010augmented aggregation\u2010induced emission (AIE) photosensitizing module into cRGD\u2010functionalized ginger\u2010derived vesicles. This architecture couples Hb\u2010associated oxygen availability with molecular confinement of the photosensitizer while harnessing the intrinsic anti\u2010inflammatory components of the plant carrier to mitigate off\u2010target toxicity. Light activation initiates a dual cascade: it induces lysosomal pyroptosis in malignant cells and disrupts key\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    pathways related to membrane transport and DNA repair. This synchronized killing elicits the coordinated release of damage\u2010 and pathogen\u2010associated molecular patterns (PAMPs), effectively transforming an immunologically cold tumor into a robust in situ vaccine that drives dendritic cell maturation and systemic T\u2010cell immunity. Our findings demonstrate that the integration of natural bioactivity with supramolecular engineering provides a biocompatible strategy for coordinated tumor\u2013bacterial disruption and immunogenic remodeling of the\n                    <jats:italic>F. nucleatum<\/jats:italic>\n                    \u2010associated tumor niche in CRC.\n                  <\/jats:p>","DOI":"10.1002\/adma.74928","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:43:47Z","timestamp":1789710227000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bio\u2010hybrid Nanostructures Orchestrate Photodynamic Remodeling of the\n                    <i>Fusobacterium nucleatum<\/i>\n                    \u2010Associated Colorectal Tumor Niche"],"prefix":"10.1002","author":[{"given":"Maliang","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Nanfang Hospital Southern 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