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Such mechano\u2010electrical coupling plays a pivotal role in tissue development, homeostasis, and repair. However, injury or pathological conditions often disrupt or weaken the local bioelectrical microenvironment, thereby limiting regenerative outcomes. Driven by the need to reconstruct the electrophysiological microenvironment, mechano\u2010electrical coupling strategies based on piezoelectric, triboelectric, magnetoelectric, and piezoionic mechanisms have emerged as a promising approach for orthopedic biomaterials. These strategies move biomaterials beyond passive structural support, enabling them to function as intelligent, self\u2010powered bioelectronic interfaces. By converting physiological motion, ultrasound, or external mechanical loading into localized and rhythmic electrical cues, these platforms can regulate cellular behavior and reshape the tissue microenvironment. 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