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Current therapies fail to address multiple pathological processes. Here, an oral administration\u2010friendly Twin\u2010Drink therapy was designed to rapidly gel in the stomach upon sequential ingestion, protecting and delivering BNBZ\u2010loaded nanoparticles (PHC NP) and the anthocyanin Cy3G. This system enables alkaline\/ROS dual\u2010response release in the microenvironment of colon inflammation. Released PHC NP inhibits tumor growth by blocking glycolysis and inducing apoptosis; Cy3G exerts anti\u2010inflammatory and microbiota remodeling effects. Twin\u2010Drink demonstrated successful endogastric gelation in a preliminary Beagle study. In the CAC mouse model, Twin\u2010Drink significantly reduced inflammation, restored colon length, and inhibited tumor occurrence. Moreover, Twin\u2010Drink enriched beneficial bacteria (e.g.,\n                    <jats:italic>Muribaculaceae<\/jats:italic>\n                    ), restored microbiota\u2010associated metabolic homeostasis, and correlated with marked improvements in MGBA\u2010mediated behavioral deficits. This study presents a drinkable, precision delivery platform for CAC management.\n                  <\/jats:p>","DOI":"10.1002\/adma.75037","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T05:37:22Z","timestamp":1789709842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twin\u2010Drink Endogastric\u2010Forming Hydrogel for Multimodal Colitis\u2010Associated Colorectal Cancer Management"],"prefix":"10.1002","volume":"38","author":[{"given":"Yuzhao","family":"Feng","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers 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