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However, seamlessly integrating electronic and microfluidic components remain challenging due to fabrication heterogeneity, material mismatches, and complex assembly requirements. In this study, we present an innovative selective laser sintering and graphitization (SLSG) 3D printing technology that enables seamless integration of 3D circuits (stereo\u2010circuits) and 3D fluidic channels (stereo\u2010fluidics). SLSG achieves unibody, autonomous mono\u2010matrix fabrication through adaptive photonic modulation of carbon\u2010rich precursors (e.g., polyetheretherketone (PEEK) powder), simultaneously creating insulating sintered structures and conductive graphitized patterns with conductivity up to 1,895 S\/m, yielding 7.64\u2010fold higher electrochemical performance than classic glassy carbon electrodes (GCEs). Using SLSG, we fabricated a watch\u2010type wearable unibody multimodal microfluidic biosensor (UMMB) with integrated electrochemical biosensors for on\u2010body sweat metabolite monitoring. UMMB incorporates stereo\u2010circuits for sensing and signal routing, plus stereo\u2010fluidic channels for sweat respiration, achieving effective lactate and glucose sensing. The device demonstrates excellent sensitivities of 29.43 and 16.86\u00a0\u00b5A\/mM for detecting lactate and glucose, respectively, while exhibiting nondetectable interference or circuit\u2010fluidic crosstalk. This novel SLSG 3D printing technology introduces a transformative unibody approach to fabricate multifunctional bioelectronic\u2010fluidic platform for integrated point\u2010of\u2010care devices, wearable sensors\/biosensors, actuators, advanced theranostics, and personalized biomedical devices.<\/jats:p>","DOI":"10.1002\/adma.75075","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:47:29Z","timestamp":1789998449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selective Laser Sintering and Graphitization for Mono\u2010Matrix Unibody Fabrication of Integrated Stereo\u2010Circuit and Stereo\u2010Fluidic Wearable Electronics"],"prefix":"10.1002","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5284-3144","authenticated-orcid":false,"given":"Wing Cheung","family":"Mak","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00502"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.matt.2020.03.020","article-title":"Skin\u2010Interfaced Sensors in Digital Medicine: From Materials to Applications","volume":"2","author":"Xu C.","year":"2020","journal-title":"Matter"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010022\u201000460\u2010x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2412423121"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303479"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2020.2987969"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsaelm.0c01129"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c12477"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2024.125865"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010023\u201000032\u2010w"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.8b00451"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010anchem\u2010061318\u2010114910"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403122"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.03.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/chemosensors11020113"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","DOI":"10.1149\/2.0121510jss","article-title":"A Paper\u2010Based Electrochemical Sensor Using Inkjet\u2010Printed Carbon Nanotube Electrodes","volume":"4","author":"Costa T. 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