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To address this issue, we exploited tumor cell invasiveness to construct isolated niches that confine the cells in micron\u2010scale chambers shielded from external microenvironmental perturbations. For proof of principle, we fabricated a hyaluronic acid\u2010based double\u2010network hydrogel comprising HAMA and PEGDA. Hyaluronidase\u2010dependent invasive tumor cells degrade the hydrogel to form isolated niches and are physically confined. The hydrogel releases DOX\/LDH\u2010engineered\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    minicells that accumulate in niches, eradicating trapped tumor cells via high local DOX concentrations. Spatial confinement enriches tumor antigens and excludes normal tissue proteins, improving LDH\u2010mediated antigen capture. Minicells then deliver antigens to dendritic cells; post\u2010phagocytosis, LDH releases antigens, and Mn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    activates the cGAS\u2010STING pathway, synergistically boosting immune activation.\n                  <\/jats:p>","DOI":"10.1002\/adma.75102","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:45:36Z","timestamp":1790257536000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting Tumor Cell Invasiveness to Construct an Isolated Niche for Postoperative Immunotherapy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7739-7830","authenticated-orcid":false,"given":"Yuxi","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Stomatology Lanzhou University  Lanzhou P. R. 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