{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:55:05Z","timestamp":1790686505620,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A defining feature of living cells is their ability to harvest environmental energy and convert it into spatially regulated biochemical work. Reconstituting such programmable bioenergetics across length scales remains a major challenge in biohybrid materials. Here, we report light\u2010addressable biohybrid nano\u2010organelles that couple plasmonic nanochemistry with biological energy transduction to enable programmable bioenergetics from nanoscale to tissue scale. A hollow Au\u2013Pt plasmonic catalytic shell is hierarchically integrated with bacterial membranes bearing\n                    <jats:italic>F<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    <jats:italic>F<\/jats:italic>\n                    <jats:sub>1<\/jats:sub>\n                    \u2010ATP synthase, yielding nano\u2010organelles that convert near\u2010infrared excitation (785\u00a0nm) into a transmembrane proton gradient (\u0394pH) and light\u2010gated ATP generation. Microfluidic encapsulation within giant unilamellar vesicles produces structurally uniform, energy\u2010autonomous protocells. Upon optical activation, plasmon\u2010enhanced glucose oxidation establishes \u0394pH\u2010driven ATP synthesis that powers spatiotemporally regulated actin polymerization, resulting in reversible, light\u2010programmable morphogenesis at the single vesicle level. When embedded in alginate\u2010based prototissues, these nano\u2010organelles provide remotely addressable metabolic support, enhancing ATP levels and matrix stiffness under oxidative stress. This work establishes a modular multiscale biohybrid platform for optically programmable bioenergetics and advances the design of energy\u2010active synthetic cell and tissue\u2010like systems.\n                  <\/jats:p>","DOI":"10.1002\/adma.75111","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:59:47Z","timestamp":1790683187000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Light\u2010Addressable Biohybrid Nano\u2010Organelles for Programmable Multiscale Bioenergetics"],"prefix":"10.1002","author":[{"given":"Sumit","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamata","family":"Karmacharya","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-1444","authenticated-orcid":false,"given":"In Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6423-1834","authenticated-orcid":false,"given":"Yoon\u2010Kyoung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Ulsan National Institute of Science and Technology (UNIST)  Ulsan South 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