{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:08:49Z","timestamp":1790683729817,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22278104"],"award-info":[{"award-number":["22278104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22325801"],"award-info":[{"award-number":["22325801"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oncolytic adenovirus (OA) exhibit tumor\u2010selective tropism, inducing direct oncolysis while simultaneously potentiating host immune responses against malignancies. However, the poor delivery efficiency of the virus targeting tumors and its limited immune activation capacity severely delays the therapeutic effect. This study proposes a kind of immunomodulator\u2014OAencapsulated with gold nanozyme (AuA), possessing peroxidase\u2010like (POD) activity, named OA@AuA. This design uses bionic mineralization method for coating OAsurface antigens, delaying their clearance during circulation and thereby increasing viral accumulation at the tumor site. The OA@AuA can consume H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    to generate reactive oxygen species (ROS), activate the cGAS\u2010STING pathway and promote the conversion of M2 macrophages to M1 macrophages. Subsequently, the tumor\u2010associated antigens and damage\u2010associated molecular patterns (DAMPs) were released, thus upregulating the expression of calreticulin (CALR) and high mobility group protein B1 (HMGB1), causing immunogenic cell death and activating tumor\u2010specific cytotoxic T cells to attack tumors, thereby reversing the tumor microenvironment. OA@AuA, as a potent immunomodulator, not only has good biocompatibility, but also breaks the immunosuppressive state in the tumor microenvironment, enhances immune infiltration in the tumor microenvironment, reverses immunosuppressive \u201ccold\u201d tumors into immunostimulatory \u201chot\u201d tumors.\n                  <\/jats:p>","DOI":"10.1002\/adma.75119","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:43:33Z","timestamp":1790682213000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanozyme\u2010Assisted Engineered Oncolytic Adenovirus for Improving Intratumoral Immune Deficiency and Enhancing Cancer Immunotherapy"],"prefix":"10.1002","author":[{"given":"Yuqing","family":"Lv","sequence":"first","affiliation":[{"name":"Center for Rehabilitation Medicine Rehabilitation and Sports Medicine Research Institute of Zhejiang Province Department of Rehabilitation Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College  Hangzhou P. R. China"},{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"},{"name":"College of Pharmacy Hangzhou Medical College  Hangzhou Zhejiang P. R. China"},{"name":"Key Discipline of Zhejiang Province in Public Health and Preventive Medicine (First Class, Category A) Hangzhou Medical College  Hangzhou Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing P. R. China"},{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aodi","family":"Niu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-6325","authenticated-orcid":false,"given":"Tong","family":"Ge","sequence":"additional","affiliation":[{"name":"Emergency Department Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital) Hangzhou Medical College  Taizhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshuang","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7967-1447","authenticated-orcid":false,"given":"Yuxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Jiao","sequence":"additional","affiliation":[{"name":"Techpool Bio\u2010pharma Co., Ltd.  Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Lei","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Women's Hospital Zhejiang University School of Medicine  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4026-7474","authenticated-orcid":false,"given":"Ketao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Colorectal and Anal Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine)  Hangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-7935","authenticated-orcid":false,"given":"Jia jia","family":"Xue","sequence":"additional","affiliation":[{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-8501","authenticated-orcid":false,"given":"Huiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic\u2010Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials &amp; Translational Engineering Laboratory Beijing Key Laboratory of Bioprocess Beijing University of Chemical Technology  Beijing P. R. China"},{"name":"Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3234-1737","authenticated-orcid":false,"given":"Xiaozhou","family":"Mou","sequence":"additional","affiliation":[{"name":"Center for Rehabilitation Medicine Rehabilitation and Sports Medicine Research Institute of Zhejiang Province Department of Rehabilitation Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College  Hangzhou P. R. China"},{"name":"Clinical Research Institute Zhejiang Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine Zhejiang Provincial People's Hospital Affiliated People's Hospital of Hangzhou Medical College Hangzhou P. R. China"},{"name":"College of Pharmacy Hangzhou Medical College  Hangzhou Zhejiang P. R. China"},{"name":"Key Discipline of Zhejiang Province in Public Health and Preventive Medicine (First Class, Category A) Hangzhou Medical College  Hangzhou Zhejiang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"7","article-title":"Cancer Statistics, 2022","volume":"72","author":"Siegel R. L.","year":"2022","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"16","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1200\/JCO.2014.60.0213","article-title":"Personalizing Colon Cancer Adjuvant Therapy: Selecting Optimal Treatments for Individual Patients","volume":"33","author":"Dienstmann R.","year":"2015","journal-title":"Journal of Clinical Oncology"},{"issue":"6346","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.aai8515","article-title":"Origins of Lymphatic and Distant Metastases in Human Colorectal Cancer","volume":"357","author":"Naxerova K.","year":"2017","journal-title":"Science"},{"issue":"8","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","article-title":"ESMO Consensus Guidelines for the Management of Patients With Metastatic Colorectal Cancer","volume":"27","author":"Van Cutsem E.","year":"2016","journal-title":"Annals of Oncology"},{"issue":"2","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.trecan.2022.10.003","article-title":"The Emerging Field of Oncolytic Virus\u2010Based Cancer Immunotherapy","volume":"9","author":"Ma R.","year":"2023","journal-title":"Trends in Cancer"},{"issue":"5","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/s41417-021-00389-3","article-title":"Oncolytic Adenoviruses Synergistically Enhance Anti\u2010PD\u2010L1 and Anti\u2010CTLA\u20104 Immunotherapy by Modulating the Tumour Microenvironment in a 4T1 Orthotopic Mouse Model","volume":"29","author":"Zhang H.","year":"2022","journal-title":"Cancer Gene Therapy"},{"issue":"2","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3390\/ijms25021180","article-title":"Oncolytic Virotherapy: A New Paradigm in Cancer Immunotherapy","volume":"25","author":"Volovat S. R.","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"19","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221910522","article-title":"Concepts in Oncolytic Adenovirus Therapy","volume":"22","author":"Mantwill K.","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2025.102319","article-title":"Cholesterol Surface\u2010Modified Oncolytic Adenovirus Enriched With Apolipoprotein E Penetrates the Blood\u2010Brain Barrier to Target Glioblastoma Immunotherapy","volume":"35","author":"Niu A.","year":"2025","journal-title":"Materials Today Bio"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114255","article-title":"ApoE\u2010Corona Oncolytic Adenovirus Nanoparticles Enable Blood\u2013Brain Barrier Penetration for Glioblastoma Immunotherapy","volume":"387","author":"Ge T.","year":"2025","journal-title":"Journal of Controlled Release"},{"issue":"2","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001486","article-title":"Clinical Landscape of Oncolytic Virus Research in 2020","volume":"8","author":"Macedo N.","year":"2020","journal-title":"Journal for ImmunoTherapy of Cancer"},{"issue":"1","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40820-022-00828-2","article-title":"Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy","volume":"14","author":"Zhang X.","year":"2022","journal-title":"Nano\u2010Micro Letters"},{"issue":"1","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1038\/s41467-018-05798-x","article-title":"Biomimetic Nanoflowers by Self\u2010Assembly of Nanozymes to Induce Intracellular Oxidative Damage Against Hypoxic Tumors","volume":"9","author":"Wang Z.","year":"2018","journal-title":"Nature Communications"},{"issue":"18","key":"e_1_2_10_15_1","doi-asserted-by":"crossref","first-page":"11994","DOI":"10.1021\/acs.analchem.9b02901","article-title":"Fe\u2013N\u2013C Single\u2010Atom Nanozymes for the Intracellular Hydrogen Peroxide Detection","volume":"91","author":"Jiao L.","year":"2019","journal-title":"Analytical Chemistry"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.biomaterials.2019.03.027","article-title":"Hypoxia Alleviation\u2010Triggered Enhanced Photodynamic Therapy in Combination with IDO Inhibitor for Preferable Cancer Therapy","volume":"206","author":"Xing L.","year":"2019","journal-title":"Biomaterials"},{"issue":"10","key":"e_1_2_10_17_1","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201802228","article-title":"Nanoparticle\u2010Enhanced Radiotherapy to Trigger Robust Cancer Immunotherapy","volume":"31","author":"Chen Q.","year":"2019","journal-title":"Advanced Materials"},{"key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.actbio.2024.02.044","article-title":"Tumor\u2010Targeted Delivery of Copper\u2010Manganese Biomineralized Oncolytic Adenovirus for Colorectal Cancer Immunotherapy","volume":"179","author":"Li Y.\u2010S.","year":"2024","journal-title":"Acta Biomaterialia"},{"issue":"38","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/aacf86","article-title":"The Effect of DNA on the Oxidase Activity of Nanoceria With Different Morphologies","volume":"29","author":"Yang D.","year":"2018","journal-title":"Nanotechnology"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102038","article-title":"Mitochondrial Transfer Between Cell Crosstalk\u2014An Emerging Role in Mitochondrial Quality Control","volume":"91","author":"Liu Y.","year":"2023","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41392-025-02253-4","article-title":"Mitochondria in Oxidative Stress, Inflammation and Aging: From Mechanisms to Therapeutic Advances","volume":"10","author":"Xu X.","year":"2025","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"e_1_2_10_22_1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev-pathmechdis-012419-032711","article-title":"Mitochondrial Dynamics and Its Involvement in Disease","volume":"15","author":"Chan D. C.","year":"2020","journal-title":"Annual Review of Pathology: Mechanisms of Disease"},{"issue":"4","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ROS Promote Mitochondrial Dysfunction and Inflammation in Ischemic Acute Kidney Injury by Disrupting TFAM\u2010Mediated mtDNA Maintenance","volume":"11","author":"Zhao M.","year":"2021","journal-title":"Theranostics"},{"issue":"2","key":"e_1_2_10_24_1","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41556-023-01343-1","article-title":"Mitochondrial DNA Replication Stress Triggers a Pro\u2010Inflammatory Endosomal Pathway of Nucleoid Disposal","volume":"26","author":"Newman L. E.","year":"2024","journal-title":"Nature Cell Biology"},{"issue":"6","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41556-024-01419-6","article-title":"TFAM Is an Autophagy Receptor That Limits Inflammation by Binding to Cytoplasmic Mitochondrial DNA","volume":"26","author":"Liu H.","year":"2024","journal-title":"Nature Cell Biology"},{"issue":"7548","key":"e_1_2_10_26_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nature14156","article-title":"Mitochondrial DNA Stress Primes the Antiviral Innate Immune Response","volume":"520","author":"West A. P.","year":"2015","journal-title":"Nature"},{"issue":"7676","key":"e_1_2_10_27_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/nature24050","article-title":"Cytoplasmic Chromatin Triggers Inflammation in Senescence and Cancer","volume":"550","author":"Dou Z.","year":"2017","journal-title":"Nature"},{"issue":"1","key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13045-020-00916-z","article-title":"cGAS\u2010STING, an Important Pathway in Cancer Immunotherapy","volume":"13","author":"Jiang M.","year":"2020","journal-title":"Journal of Hematology & Oncology"},{"key":"e_1_2_10_29_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216409","article-title":"cGAS\u2010STING Signaling in the Tumor Microenvironment","volume":"577","author":"Liu Z.","year":"2023","journal-title":"Cancer Letters"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.jconrel.2021.02.018","article-title":"Overcoming the Barriers to Optimization of Adenovirus Delivery Using Biomaterials: Current Status and Future Perspective","volume":"332","author":"Kasala D.","year":"2021","journal-title":"Journal of Controlled Release"},{"issue":"1","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-55043-x","article-title":"Coxsackievirus and Adenovirus Receptor Expression Facilitates Enteroviral Infections to Drive the Development of Pancreatic Cancer","volume":"15","author":"Bastea L. I.","year":"2024","journal-title":"Nature Communications"},{"issue":"28","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"18282","DOI":"10.1021\/acsnano.4c01115","article-title":"Enhancing the Antitumor Efficacy of Oncolytic Adenovirus Through Sonodynamic Therapy\u2010Augmented Virus Replication","volume":"18","author":"Ding J.","year":"2024","journal-title":"ACS Nano"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.574007","article-title":"Extracellular Vesicles\u2010Mimetic Encapsulation Improves Oncolytic Viro\u2010Immunotherapy in Tumors With Low Coxsackie and Adenovirus Receptor","volume":"8","author":"Zhang Y.","year":"2020","journal-title":"Frontiers in Bioengineering and Biotechnology"},{"issue":"9","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of Nanoparticle Design for Overcoming Biological Barriers to Drug Delivery","volume":"33","author":"Blanco E.","year":"2015","journal-title":"Nature Biotechnology"},{"issue":"17","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202304136","article-title":"Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic\u2010Immune Combination Therapy for Colorectal Cancer","volume":"13","author":"Ye L.\u2010Y.","year":"2024","journal-title":"Advanced Healthcare Materials"},{"issue":"8","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1093\/annonc\/mdw217","article-title":"Immune Escape to PD\u2010L1\/PD\u20101 Blockade: Seven Steps to Success (or failure)","volume":"27","author":"Kim J. M.","year":"2016","journal-title":"Annals of Oncology"},{"issue":"1","key":"e_1_2_10_37_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01489-2","article-title":"Combination Strategies With PD\u20101\/PD\u2010L1 Blockade: Current Advances and Future Directions","volume":"21","author":"Yi M.","year":"2022","journal-title":"Molecular Cancer"},{"issue":"6","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2017.08.027","article-title":"Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti\u2010PD\u20101 Immunotherapy","volume":"170","author":"Ribas A.","year":"2017","journal-title":"Cell"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.75119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:43:39Z","timestamp":1790682219000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.75119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":37,"alternative-id":["10.1002\/adma.75119"],"URL":"https:\/\/doi.org\/10.1002\/adma.75119","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75119"}}