{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:04:40Z","timestamp":1790262280481,"version":"4.1.0"},"reference-count":75,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The structural anisotropy of collagen is essential for the function of tissues such as articular cartilage, yet current biofabrication strategies fail to reproduce this hierarchical organization. Melt electrowriting (MEW) is widely used to fabricate mechanically stable polycaprolactone (PCL) scaffolds for reinforcing hydrogels in cartilage tissue engineering, but these constructs typically develop randomly organized collagen networks during chondrogenic differentiation, both in vitro and in vivo. Here, we introduce melt electrofibrillation (MEF), a variation of MEW, as a promising strategy to produce nanofibrillar PCL scaffolds with defined architectures for cartilage tissue engineering. We demonstrate that MEF PCL scaffolds promote enhanced cellular alignment and retention while consistently guiding the organization of a collagen type II\u2010rich extracellular matrix. As a result, MEF provides a tunable, printable scaffold for directing organized cartilage matrix formation. This approach represents a significant step toward engineering biomimetic cartilage and potentially other aligned, collagen\u2010rich tissues with controlled structural organization.<\/jats:p>","DOI":"10.1002\/adma.75138","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:16:41Z","timestamp":1790259401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fabrication of Aligned Polycaprolactone Nanofibrillar Bundles to Control Cell\u2010Mediated Collagen Deposition in Engineered Cartilage"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1019-331X","authenticated-orcid":false,"given":"Alba","family":"Pueyo Moliner","sequence":"first","affiliation":[{"name":"University Medical Center Utrecht &amp; Regenerative Medicine Center Utrecht  Utrecht the Netherlands"},{"name":"Department of Equine Sciences Faculty of Veterinary Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0405-7196","authenticated-orcid":false,"given":"Lennard","family":"Spauwen","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht &amp; 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Regenerative Medicine Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-913X","authenticated-orcid":false,"given":"Aylin","family":"Kara \u00d6zenler","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht &amp; Regenerative Medicine Center Utrecht  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-4476","authenticated-orcid":false,"given":"Matthias","family":"Ryma","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry Institute for Functional Materials and Biofabrication and Center of Polymers for Life (CPL) University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-8466","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Groll","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry Institute for Functional Materials and Biofabrication and Center of Polymers for Life (CPL) University of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8685-8379","authenticated-orcid":false,"given":"Myl\u00e8ne","family":"de Ruijter","sequence":"additional","affiliation":[{"name":"University Medical Center Utrecht &amp; 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