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Existing liquid\u2013liquid phase separation (LLPS)\u2010based adhesives mainly exploit phase condensation for interfacial wetting, while the phase\u2010separated domains rarely participate in active molecular reinforcement or adaptive mechanical regulation. Inspired by the hydration\u2010regulated adaptive transition behavior of snail mucus, we herein constructed an adaptive coacervate adhesive through an phase\u2010confined structure transformation and dual\u2010network reinforcement. Through salt bridge\u2010mediated phase separation between sodium thioctate and polycationic components, dense coacervate condensates are formed via synergistic salt\u2010bridge interactions, providing highly confined microenvironments for realizing the ring\u2010opening polymerization (ROP) of thioctic acid (TA). Consequently, the coacervate adhesive undergoes hydration\u2010regulated reversible mechanical transition, featuring superior wet interfacial adaptability under the hydrated state and substantial dehydration\u2010induced stiffening and cohesive reinforcement analogous to native snail mucus. Unlike conventional tissue sealants and sutures that often suffer from poor wet adaptability or rigid fixation, the adaptive coacervate system dynamically couples rapid interfacial wetting with dehydration\u2010induced cohesive reinforcement (695.31\u00a0vs 24.7 N\u00b7m\n                    <jats:sup>\u22122<\/jats:sup>\n                    of fibrin glue). This work establishes a universal biomimetic strategy for coupling confined molecular structural transformation with adaptive supramolecular mechanics toward designing adaptive biointerfaces.\n                  <\/jats:p>","DOI":"10.1002\/adma.75175","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:16:57Z","timestamp":1790662617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phase\u2010Confined Ring\u2010Opening Polymerization Enables Adaptive Wet Adhesion with Dynamic Mechanical Reinforcement"],"prefix":"10.1002","author":[{"given":"Tongye","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyue","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Infusion Implantable and Interventional Medical Devices Shandong Weigao Group Medical Polymer Products Co., Ltd. Weihai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunjie","family":"Yan","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Infusion Implantable and Interventional Medical Devices Shandong Weigao Group Medical Polymer Products Co., Ltd. Weihai P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7549-0388","authenticated-orcid":false,"given":"Hengchong","family":"Shi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4395-5002","authenticated-orcid":false,"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-9010","authenticated-orcid":false,"given":"Shifang","family":"Luan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Polymer Science and Technology Changchun Institute of Applied Chemistry Chinese Academy of Sciences  Changchun P. R. China"},{"name":"School of Applied Chemistry and Engineering University of Science and Technology of China  Hefei P. R. 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