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In contrast, synthetic separation membranes mainly achieve selectivity through controlled pore size and surface chemistry, facing challenges in separating molecules that differ subtly in shape or stereochemistry. Here we report self\u2010assembled polymeric membranes with sinuous 3D nanochannels whose intrinsic saddle\u2013splay geometry boosts chiral separation. Freestanding nanoporous membranes are readily fabricated by photocuring lyotropic double\u2010gyroid (GYR) liquid crystals (LCs) formed from amphiphiles bearing chiral moieties. Spatial variation in saddle\u2013splay curvature within these GYR nanochannels clusters chiral selectors into precisely positioned \u201ccheckpoints\u201d and imposes strong nanoconfinement, forcing racemates to repeatedly traverse these unavoidable stereoselective sites that cumulatively amplify enantioselectivity. The highly permeable membranes achieve enantiopure separation of model racemates such as ibuprofen, with selectivity nearly 10\u2010fold higher than their counterparts with sheet\u2010like or cylindrical\u2010mesh pores of comparable chemistry and size. This work establishes sinuous 3D nanochannels with saddle\u2010splay curvature as a biomimetic structural motif for amplifying chiral recognition in synthetic membranes.<\/jats:p>","DOI":"10.1002\/adma.75177","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:57:26Z","timestamp":1790762246000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Boosting Chiral Separation Through Sinuous 3D Nanochannels With Saddle\u2013Splay Curvature in Biomimetic Membranes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5958-6729","authenticated-orcid":false,"given":"Xiang","family":"Liang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Center For Advanced Low\u2010Dimension Materials and College of Materials Science and Engineering Donghua University  Shanghai 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For High Pressure Science and Technology Advanced Research  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0229-7712","authenticated-orcid":false,"given":"Xinglin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Environmental Technology Department of Environmental Science and Engineering University of Science and Technology of China  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1087-2868","authenticated-orcid":false,"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Mathematical Sciences ShanghaiTech University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0450-2406","authenticated-orcid":false,"given":"Yizhou","family":"Zhang","sequence":"additional","affiliation":[{"name":"Advanced Institute for Materials Research (WPI\u2010AIMR) Tohoku University  Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6338-2411","authenticated-orcid":false,"given":"Pawel W.","family":"Majewski","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Warsaw  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-0769","authenticated-orcid":false,"given":"Xunda","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Fiber Materials Center For Advanced Low\u2010Dimension Materials and College of Materials Science and Engineering Donghua University  Shanghai 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