{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:51:18Z","timestamp":1791532278017,"version":"4.3.4"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22622501"],"award-info":[{"award-number":["22622501"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22579011"],"award-info":[{"award-number":["22579011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52303363"],"award-info":[{"award-number":["52303363"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52625315"],"award-info":[{"award-number":["52625315"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Photocatalytic two\u2010electron oxygen reduction reaction (ORR) toward H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    synthesis is a compelling approach for clinical antibacterial applications. Yet its selectivity is hampered by the competing four\u2010electron ORR, which compromises both H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    generation kinetics and antibacterial efficiency. Herein, we report a new nanoscale confinement strategy for the controllable synthesis of covalent organic frameworks (COFs) confining isolated platinum nanoclusters (NCs) to enhance Pauling\u2010type of O\n                    <jats:sub>2<\/jats:sub>\n                    adsorption to achieve two\u2010electron oxygen reduction for efficient antibacterial therapy. The resulting Tfp\u2010Db COFs@Pt NCs exhibits a significantly higher H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    formation kinetics (3.12 \u00d7 10\u2212\n                    <jats:sup>3<\/jats:sup>\n                    \u00a0mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) than Tfp\u2010Db COFs@Pt nanoparticles (1.55 \u00d7 10\n                    <jats:sup>\u22123<\/jats:sup>\n                    \u00a0mol L\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0h\n                    <jats:sup>\u22121<\/jats:sup>\n                    ), with 2e\n                    <jats:sup>\u2212<\/jats:sup>\n                    ORR selectivity increased from 45.0% to 86.0%. Experimental and theoretical results reveal a two\u2010step single electron oxygen reduction pathway for H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    photosynthesis over Tfp\u2010Db COFs@Pt NCs. The Tfp\u2010Db COFs@Pt NCs exhibits excellent sterilization efficiencies of 5.0 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    and 5.2 log\n                    <jats:sub>10<\/jats:sub>\n                    CFU mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    , respectively, exceeding most reported materials. Furthermore, Tfp\u2010Db COFs@Pt NCs facilitate the regeneration of infectious wounds, with the efficiency of nearly 100% on day 10, outperforming previously reported bionanomaterials. Collectively, this work presents a new strategy for regulating the Pauling\u2010type of O\n                    <jats:sub>2<\/jats:sub>\n                    adsorption to enhance the photocatalytic H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    formation for wound healing application.\n                  <\/jats:p>","DOI":"10.1002\/adma.75228","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:39:49Z","timestamp":1791531589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nanocavity Confining Platinum Nanoclusters Enhances Photocatalytic Two\u2010Electron Oxygen Reduction for Wound Healing"],"prefix":"10.1002","author":[{"given":"Yaru","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-6861","authenticated-orcid":false,"given":"Shihan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QinQin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Beijing University of Chemical Technology Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7684-9997","authenticated-orcid":false,"given":"Yachao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Beijing University of Chemical Technology Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Medical Technology Peking University Health Science Center  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-8785","authenticated-orcid":false,"given":"Youxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"},{"name":"College of Materials Science and Engineering, Beijing University of Chemical Technology Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1838-6274","authenticated-orcid":false,"given":"Xuliang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Dentistry School and Hospital of Stomatology School of Materials Science and Engineering Peking University  Beijing P. R. 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