{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:51:55Z","timestamp":1791103915330,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571533"],"award-info":[{"award-number":["32571533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32222090"],"award-info":[{"award-number":["32222090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32571609"],"award-info":[{"award-number":["32571609"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013050","name":"Guangdong Provincial Applied Science and Technology Research and Development Program","doi-asserted-by":"publisher","award":["2024A1515011140"],"award-info":[{"award-number":["2024A1515011140"]}],"id":[{"id":"10.13039\/501100013050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neutrophil extracellular traps (NETs) perpetuate chronic inflammation in ulcerative colitis (UC), yet current neutrophil\u2010targeting therapies focus on acute intervention rather than sustained daily control. Here, we propose an oral microsupplement for long\u2010term UC management that concurrently scavenges reactive oxygen species (ROS) and suppresses NET formation. The microsupplement integrates a catalase\u2010mimetic CoAl\u2010layered double hydroxide (LDH) nanozyme intercalated with the autophagy inhibitor chloroquine (CQ), together with dopamine (DOPA). The LDH nanozyme catalytically converts pathological ROS into oxygen, driving in situ polymerization of DOPA into polydopamine (PDA), a mucoadhesive polymer that prolongs colonic retention of CQ@LDH and promotes mucosal healing. RNA sequencing reveals that internalized CQ@LDH inhibits autophagic flux in neutrophils, thereby upregulating catalase expression and peroxisomal function to prevent NET formation. Consequently, NET\u2010driven M1 macrophage polarization is reduced from 29.5% to 17.9%, and Th17 differentiation is markedly suppressed, accompanied by a decrease in colonic Th17\/Treg ratio from 8.68 to 1.31. In a murine UC model, this microsupplement restores colonic mucosal integrity, rebalances the gut microbiota, and outperforms the clinical drug 5\u2010aminosalicylic acid in both immune regulation and epithelial restitution. This neutrophil\u2010regulating, colon\u2010adhesive platform offers a promising strategy for routine daily UC management.<\/jats:p>","DOI":"10.1002\/adma.75234","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:58:37Z","timestamp":1791100717000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Oral Nanozyme Microsupplement Converts Pathological ROS Into a Colon\u2010Adhesive Shield for Long\u2010Term Neutrophil\u2010Directed Remission of Ulcerative Colitis"],"prefix":"10.1002","author":[{"given":"Xinying","family":"Yu","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinwang","family":"Yu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7156-8398","authenticated-orcid":false,"given":"Ziliang","family":"Yan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songhao","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhao","family":"Feng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3918-8404","authenticated-orcid":false,"given":"Kai","family":"Luo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8863-884X","authenticated-orcid":false,"given":"Meifang","family":"Wang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6901-6420","authenticated-orcid":false,"given":"Bei","family":"Li","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4023-7320","authenticated-orcid":false,"given":"Yunlu","family":"Dai","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Macau  Macau SAR China"},{"name":"MoE Frontiers Science Center for Precision Oncology University of Macau  Macau SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V130.Suppl_1.994.994"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010023\u201000871\u20103"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.183"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010844530"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1279837"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028172\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1102942"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301780R"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201046025\u20100"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102249.2010.04279.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526\u20100968.2003.00012.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.24"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.01.006"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572\u2010020\u20100205\u2010x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201067371\u20105"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00377\u20100"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.029"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc0441"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201041468\u20109"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1147241"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1sc05512g"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.14"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf400150p"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy215"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201010\u2010463646"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20148"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21030"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21282"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13997"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574\u2010695X.2007.00329.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3023"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900820"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41686"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201043554\u2010y"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3700"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2022.06.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.12.002"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.09.017"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1708"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0415\u2010165RR"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401867"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1083072"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401320"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.06.006"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107906"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.150"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa8064"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20100538\u20105"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010017\u201003956\u20107"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15463"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102016\u2010210426"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2017.03.033"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10404\u2010023\u201002655\u20102"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010024\u201002049\u2010y"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.044"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2022.07.005"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12029"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2024.09.006"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564\u2010021\u201001050\u20103"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168\u2010023\u201001722\u20108"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042788\u20100"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00906"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.794746"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)00966\u20102"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.102139"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2026.01.016"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162172"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75234","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.75234","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:58:38Z","timestamp":1791100718000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.75234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":72,"alternative-id":["10.1002\/adma.75234"],"URL":"https:\/\/doi.org\/10.1002\/adma.75234","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75234"}}