{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:51:51Z","timestamp":1791103911116,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immunotherapy for colorectal cancer liver metastasis is often compromised by a highly immunosuppressive hepatic microenvironment characterized by tolerogenic macrophages that act as a systemic immune sink. Here, given the potent but systemically toxic antitumor profile of interferon\u2010\u03b3 (IFN\u2010\u03b3), we engineered hepatic macrophage\u2010targeted cytokine\u2010expressing platelet\u2010like microparticles (HM\u2010CPMP) for the local delivery of IFN\u2010\u03b3, thereby reprogramming the immune status of the liver. Mechanistically, HM\u2010CPMP treatment drove extensive M1\u2010like macrophage polarization and a CXCL9\/10 chemotactic axis, which together shifted the liver from a tolerogenic to a pro\u2010inflammatory state. Therefore, systemic administration of HM\u2010CPMP facilitated the clearance of established liver metastases and conferred a marked survival benefit while strictly preserving systemic homeostasis. Intravital imaging revealed that this localized innate immune reprogramming broke the immunosuppressive tumor niche and recruited polyfunctional CXCR6\n                    <jats:sup>+<\/jats:sup>\n                    and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to eradicate metastatic cells. Collectively, by enabling precise hepatic immune modulation, the cytokine\u2010expressing platelet\u2010like microparticle delivery platform unleashes a potent localized antitumor response while preserving systemic homeostasis. Our findings provide a highly translational clinical strategy for biosynthetic cytokine\u2010based immunotherapy against liver metastases.\n                  <\/jats:p>","DOI":"10.1002\/adma.75242","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:55:28Z","timestamp":1791100528000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineered IFN\u2010\u03b3\u2010Expressing Platelet\u2010Like Microparticles Trigger Macrophage\u2010Targeted Immunity to Eradicate Liver Metastases"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-5146","authenticated-orcid":false,"given":"Ren","family":"Zhang","sequence":"first","affiliation":[{"name":"MOE Key Laboratory For Biomedical Photonics Wuhan National Laboratory For Optoelectronics\u2010Huazhong University of Science and Technology  Wuhan Hubei 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