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Herein, we engineer an albumin\u2010based photodynamic conversion nanoparticles integrating target\u2010specific recognition with controlled antibacterial functions to precisely eliminate intracellular pathogens and restore infected cell activity. Mechanistic studies reveal a vertically\u2010crossed conformation that promotes intramolecular electron transfer and charge separation, redirecting photosensitizer (PS) reactivity toward type\u2010I reactive oxygen species (ROS) generation. Electron\u2010rich albumin further enhances cationic PS\n                    <jats:sup>+\u2022<\/jats:sup>\n                    recycling, photostability, and O\n                    <jats:sub>2<\/jats:sub>\n                    <jats:sup>\u2212\u2022<\/jats:sup>\n                    production, while its selective cytoplasmic delivery via receptor\/charge interactions enables preferential accumulation in intracellular bacteria, with reduced off\u2010target organelle engagement. We demonstrate application in\n                    <jats:italic>S. aureus<\/jats:italic>\n                    \u2010infected sepsis showing high type\u2010I ROS levels for antibacterial function from the nanoparticles to restore redox and immune homeostasis without noticeable toxicity. This work pioneers a conformationally\u2010gated ROS conversion approach for eliminating intracellular bacterial infections, merging mechanistic precision with therapeutic potential for clinical sepsis management.\n                  <\/jats:p>","DOI":"10.1002\/adma.75340","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:38:33Z","timestamp":1791783513000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Albumin Orchestrates Type\u2010I ROS Conversion for Efficient Intracellular Bacterial Clearance"],"prefix":"10.1002","author":[{"given":"Bin","family":"Fang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Flexible Electronics (IFE) School of Advanced Interdisciplinary Biomedical Sciences Xiamen University  Xiamen 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Materials Science Northwest University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7318-8927","authenticated-orcid":false,"given":"Xuekang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Burns and Cutaneous Surgery Xijing Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0426-6546","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; Institute of Flexible Electronics (IFE) School of Advanced Interdisciplinary Biomedical Sciences Xiamen University  Xiamen China"},{"name":"State Key Laboratory of Flexible Electronics (LoFE) &amp; School of Flexible Electronics (SoFE) Northwestern Polytechnical University  Xi'an 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