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Here, a customized therapeutic strategy is presented for multiple tumors by using the same prescription based on a multi\u2010channel lanthanide nanocomposite and orthogonally controlled drug release. The upconversion luminescence of the nanocomposite at different wavelengths can monitor pH\u2010responsive mitoxantrone (MXT) release, reduced glutathione\u2010responsive near\u2010infrared (NIR) absorbance change, and eigen temperature, respectively, allowing modulation of photothermal treatment and temperature\u2010responsive paclitaxel release through customized whole\u2010body irradiation to achieve synchronized ablation of different individual tumors. Small animal experiments confirm multifocal breast tumors can be treated through this customized therapeutic strategy with both high efficiency and low overtherapy risk.<\/jats:p>","DOI":"10.1002\/adma.75392","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:31:27Z","timestamp":1791988287000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronized Ablation of Multifocal Tumors Enabled by Multi\u2010Channel Lanthanide Nanocomposites"],"prefix":"10.1002","author":[{"given":"Fang","family":"Li","sequence":"first","affiliation":[{"name":"School of Physical Science and Technology &amp; State Key Laboratory of Advanced Medical Materials and Devices ShanghaiTech University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3143-4720","authenticated-orcid":false,"given":"Zheng","family":"Wei","sequence":"additional","affiliation":[{"name":"Van\u2019 t Hoff Institute For Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6771-5102","authenticated-orcid":false,"given":"Francesco G.","family":"Mutti","sequence":"additional","affiliation":[{"name":"Van\u2019 t Hoff Institute For Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Van\u2019 t Hoff Institute For Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8227-2522","authenticated-orcid":false,"given":"Felix F.","family":"Loeffler","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Systems Max\u2010Planck Institute of Colloids and Interfaces  Potsdam Germany"},{"name":"Institute for Molecular and Multimaterial Manufacturing Hamburg University of Technology  Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2080-487X","authenticated-orcid":false,"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Van\u2019 t Hoff Institute For Molecular Sciences University of Amsterdam  Amsterdam The Netherlands"},{"name":"Department of Biomolecular Systems Max\u2010Planck Institute of Colloids and Interfaces  Potsdam Germany"},{"name":"Department of Chemistry University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7507-1781","authenticated-orcid":false,"given":"Xingjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Physical Science and Technology &amp; 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