{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:39:52Z","timestamp":1792647592397,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFF0523700"],"award-info":[{"award-number":["2025YFF0523700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302405"],"award-info":[{"award-number":["82302405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501215"],"award-info":[{"award-number":["32501215"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Electrical stimulation accelerates peripheral nerve regeneration, yet current strategies are limited by wired interfaces, percutaneous leads, nondegradable components, and poor capacity for dynamic functional monitoring within the same subject. Here, we report biodegradable capacitive\u2010coupling bioelectronics (CCB), an implantable platform integrating wireless electrical stimulation, regenerative guidance, and longitudinal electrophysiological monitoring. The CCB comprises biodegradable molybdenum electrodes, Mo\u2010wire interconnects, and a textile\u2010reinforced electroactive bioelectronic nerve guidance conduit (Bio\u2010NGC). Capacitive coupling between external and implanted electrodes enables battery\u2010free wireless delivery of electrical cues to regenerating nerves, while the same architecture allows repeated recording of regenerated compound nerve action potentials (CNAPs). In a rat sciatic nerve defect model, CCB\u2010mediated stimulation enhances Schwann cell (SC) activation, mitochondrial bioenergetics, axonal regeneration, remyelination, angiogenesis, and motor recovery, with multiple outcomes approaching those of autograft repair. Mechanistic analyses revealed coordinated neurovascular remodeling, pro\u2010regenerative immune modulation, calcium\u2010related signaling, AMPK\u2010associated energy metabolism, and neurotrophic factor expression. Importantly, CCB\u2010enabled monitoring captured regeneration trajectories in the same animal without repeated nerve exposure, showing temporal trends consistent with conventional wired electrophysiology. This work establishes a biodegradable therapeutic\u2010monitoring bioelectronic platform and advances peripheral nerve repair from passive conductive scaffolds toward intelligent implantable bioelectronics.<\/jats:p>","DOI":"10.1002\/adma.75437","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:20:49Z","timestamp":1792646449000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biodegradable Capacitive\u2010Coupling Bioelectronics for Wireless Electrical Stimulation and Longitudinal Electrophysiological Monitoring of Peripheral Nerve Regeneration"],"prefix":"10.1002","author":[{"given":"Yunjie","family":"Jin","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-878X","authenticated-orcid":false,"given":"Renyuan","family":"Sun","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine Research Center for Intelligent Fiber Devices and Equipment College of Life Science and Technology Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenliang","family":"Liu","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine Research Center for Intelligent Fiber Devices and Equipment College of Life Science and Technology Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhen","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"},{"name":"Hubei Jiangxia Laboratory  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiru","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlin","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine Research Center for Intelligent Fiber Devices and Equipment College of Life Science and Technology Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7619-0707","authenticated-orcid":false,"given":"Weilin","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7080-1212","authenticated-orcid":false,"given":"Chao","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"},{"name":"Hubei Jiangxia Laboratory  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-6607","authenticated-orcid":false,"given":"Zhiqiang","family":"Luo","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Nanomedicine Research Center for Intelligent Fiber Devices and Equipment College of Life Science and Technology Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2980-1384","authenticated-orcid":false,"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering School of Biomedical Engineering and Health State Key Laboratory of New Textile Materials and Advanced Processing Wuhan Textile University  Wuhan China"},{"name":"Hubei Jiangxia Laboratory  Wuhan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202509425"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202302997"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033089\u2010z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307896"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202510948"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765\u2010025\u201000590\u20101"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.12.035"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.03.017"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202400217"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CS00413B"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2026.04.029"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202514954"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c07285"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c10653"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt0318"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201068619\u20106"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202310483"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201069226\u20101"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202313672"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416548"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav9847"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c08287"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100054"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nsr\/nwaf557"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu5887"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matt.2024.11.020"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c00845"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abo3209"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202200261"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c18775"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202520323"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201066779\u20105"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3131879"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202507931"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202523237"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055118\u20109"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007334\u2010y"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121288"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000604"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75437","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.75437","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:20:50Z","timestamp":1792646450000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.75437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,21]]},"references-count":40,"alternative-id":["10.1002\/adma.75437"],"URL":"https:\/\/doi.org\/10.1002\/adma.75437","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,21]]},"assertion":[{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75437"}}