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However, lyophilizing mammalian cells remains challenging due to their vulnerability to coupled stresses, including ice\u2010induced mechanical injury and membrane destabilization during freezing and dehydration. In nature, stress\u2010resistant plant cells survive extreme conditions through multifunctional cell walls. Inspired by their natural survival strategies, we engineer an artificial membrane armor (AMA) that enables efficient lyophilization of red blood cells (RBCs). This biomimetic AMA integrates a nanoporous zeolitic imidazolate framework (ZIF\u20108) for mechanical support, a water\u2010retentive polymer matrix for hydration retention and colloidal stabilization, and Zn\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    coordination preserves membrane fluidity and suppresses freeze\u2010 and dehydration\u2010driven membrane phase transitions. Through synergistic interfacial protection, the AMA effectively buffers coupled stresses associated with lyophilization, enabling \u223c95% post\u2010rehydration recovery of RBCs using an ultra\u2010low protectant content (&lt;5 wt%) together with an ambient shelf\u2010life of at least 3 months, unachievable with previous methods. Furthermore, the rehydrated RBCs preserve their native morphology, membrane mechanics, metabolic activity, oxygen transport capability, and in vivo circulation behavior. This work establishes a bioinspired interfacial engineering strategy for transferring desiccation tolerance from plants to mammalian cells, advancing ambient\u2010temperature biostorage of sensitive living systems.\n                  <\/jats:p>","DOI":"10.1002\/adma.75447","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T10:27:45Z","timestamp":1792319265000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Stress\u2010Resistant Plant Cell\u2010Wall Inspired Cell Armor Enables Red Blood Cell Lyophilization"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-6038","authenticated-orcid":false,"given":"Xia","family":"Zheng","sequence":"first","affiliation":[{"name":"Interdisciplinary Research Center for Advanced Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"},{"name":"Assisted Reproduction Unit Department 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