{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:44:39Z","timestamp":1792413879031,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Materials"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tomographic volumetric printing (TVP) enables rapid fabrication of complex, centimeter\u2010scale 3D architectures. TVP of native proteins such as collagen is attractive because it preserves native bioactive motifs that regulate cell\u2013matrix signaling. However, direct TVP of collagen remains challenging because dityrosine crosslinking, driven by visible\u2010light\u2010activated Ru(II)bpy\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>2+<\/jats:sup>\n                    \/sodium persulfate (SPS), lacks an effective inhibitory mechanism. This results in near\u2010immediate crosslinking upon light exposure, leading to an insufficient nonlinear threshold response that fails to suppress background curing. Here, we introduce vitamin C (L\u2010ascorbic acid) as a biocompatible redox regulator to overcome this limitation. We demonstrated that vitamin C established a photo\u2010redox threshold by suppressing Ru(III) accumulation and scavenging persulfate radicals within the Ru\/SPS system, thereby delaying dityrosine crosslinking until vitamin C depletion. This threshold generated the nonlinear response required for TVP, enabling high\u2010fidelity volumetric printing of collagen. Post\u2010printing construct densification (\u223c53% shrinkage) further improved feature resolution (80\u00a0\u00b5m positive; 120\u00a0\u00b5m negative) and yielded mechanically stable and highly stretchable hydrogels (up to 180% strain). Collagen resin with vitamin C supported both cell seeding post\u2010printing and cell\u2010laden printing with high cell density and viability, enabling the rapid biofabrication of cell\u2010instructive 3D microenvironments.\n                  <\/jats:p>","DOI":"10.1002\/adma.75454","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:09:29Z","timestamp":1792411769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamin C\u2010Induced Photo\u2010Redox Threshold Enables High\u2010Fidelity Volumetric Printing of Collagen"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-403X","authenticated-orcid":false,"given":"Bin","family":"Wang","sequence":"first","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-6195","authenticated-orcid":false,"given":"Amelia","family":"Hasenauer","sequence":"additional","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2620-1304","authenticated-orcid":false,"given":"Kristian","family":"Ivkovic","sequence":"additional","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8322-4993","authenticated-orcid":false,"given":"Ann\u2010Sophie","family":"Frind","sequence":"additional","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8934-9441","authenticated-orcid":false,"given":"David","family":"Fercher","sequence":"additional","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8522-9909","authenticated-orcid":false,"given":"Marcy","family":"Zenobi\u2010Wong","sequence":"additional","affiliation":[{"name":"Tissue Engineering + Biofabrication Laboratory Department of Health Sciences and Technology ETH Z\u00fcrich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000218\u2010w"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00134"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau7114"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014630\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578\u2010025\u201000785\u20103"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201028013\u20104"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202102900"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202210136"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202110054"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904209"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1557\/s43579-023-00447-x","article-title":"A Review of Materials Used in Tomographic Volumetric Additive Manufacturing: J. Madrid\u2010Wolff et\u00a0al.","volume":"13","author":"Madrid\u2010Wolff J.","year":"2023","journal-title":"MRS Communications"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202405105"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202409355"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.6b00454"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1132670"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050733"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.05.040"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6020"},{"key":"e_1_2_9_20_1","unstructured":"B.Wang W. S. H.Safari S.Kaveh Hedayati et\u00a0al. 2023\u201cLateral Contrast Enhancement in Tomographic Volumetric 3D\u2010Printing via Binary Photoinhibition \u201dPreprint bioRxiv March 24 https:\/\/doi.org\/10.48550\/arXiv.2303.13941.."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr3005197"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ma00148a034"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202508729"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003376"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0291888"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201035807\u20107"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adu5793"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202304846"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010017\u20102084\u20109"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201031566\u2010z"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100322"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00094a017"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6b00107"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2003.10719272"},{"key":"e_1_2_9_35_1","article-title":"Antioxidant Ascorbic Acid Influences Cell\u2010Mediated Alterations in Localized Hydrogel Crosslinking and Affects Neo\u2010Cartilage Connectivity in Hydrolytically Degradable Hydrogels","volume":"7","author":"Maples M. M.","year":"2026","journal-title":"Macromolecular Bioscience"},{"key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1021\/acsbiomaterials.6b00149","article-title":"New Visible\u2010Light Photoinitiating System for Improved Print Fidelity in Gelatin\u2010Based Bioinks","volume":"2","author":"Lim K. S.","year":"2016","journal-title":"ACS Biomaterials Science & Engineering"},{"key":"e_1_2_9_37_1","doi-asserted-by":"crossref","unstructured":"A.Nunes A.Pramanick D.Kelly et\u00a0al.2026\u201cDityrosine Photocrosslinking of Native Collagen Bioinks for Controlled Shape\u2010Fidelity of Bioprinted Cardiac Tissue Constructs: Probing the Interplay Between Fibrillogenesis and Covalent Bond Formation.\u201d Preprint bioRxiv January 14.","DOI":"10.64898\/2026.01.13.699021"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105144"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5c00117"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201014997\u20104"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201039886\u20104"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201009436\u20107"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.481318"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201056852\u20104"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.18063\/ijb.v6i3.270"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44385\u2010025\u201000018\u2010w"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010026\u201010114\u20105"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202501052"}],"container-title":["Advanced Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/adma.75454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/adma.75454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:09:30Z","timestamp":1792411770000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/adma.75454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":47,"alternative-id":["10.1002\/adma.75454"],"URL":"https:\/\/doi.org\/10.1002\/adma.75454","archive":["Portico"],"relation":{},"ISSN":["0935-9648","1521-4095"],"issn-type":[{"value":"0935-9648","type":"print"},{"value":"1521-4095","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e75454"}}