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For these patients, alveolar bone augmentation and acceleration of osseointegration optimize implant stability. Traditional oral surgery often requires invasive procedures, which can result in prolonged treatment time and associated morbidity. It has been previously shown that chemical vapor deposition (CVD) polymerization of functionalized [2.2]paracyclophanes can be used to anchor gene encoding vectors onto biomaterial surfaces and local delivery of a bone morphogenetic protein (BMP)\u2010encoding vector can increase alveolar bone volume and density in vivo. This study is the first to combine the use of CVD technology and BMP gene delivery on titanium for the promotion of bone regeneration and bone to implant contact in vivo. BMP\u20107 tethered to titanium surface enhances osteoblast cell differentiation and alkaline phosphatase activity in vitro and increases alveolar bone regeneration and % bone to implant contact similar to using high doses of exogenously applied BMP\u20107 in vivo. The use of this innovative gene delivery strategy on implant surfaces offers an alternative treatment option for targeted alveolar bone reconstruction.<\/jats:p>","DOI":"10.1002\/admi.202200531","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T04:09:38Z","timestamp":1656130178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["BMP Gene\u2010Immobilization to Dental Implants Enhances Bone Regeneration"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-7826","authenticated-orcid":false,"given":"Shogo","family":"Maekawa","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  188 Longwood Avenue Boston MA 02115 USA"},{"name":"Department of Periodontology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University  Tokyo 113\u20105810 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