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This study investigates how tuning granular hydrogel properties influences lymphatic tube formation. Microgels were fabricated using norbornene\u2010modified hyaluronic acid (NorHA) via pipetting or vortexing for 90 s (V90s) and 180 s (V180s), then assembled into granular hydrogels under loose and tight packing conditions. These conditions produced gels with varied pore morphologies and bulk rheological properties. Lymphatic capillary formation occurred only in tightly packed gels, where mechanical properties converged, highlighting the importance of gel morphology over stiffness. V180s samples showed earlier vessel formation as seen in lymphatic gene and protein expression, while pipetted gels exhibited greater capillary connectivity, forming larger vessel clusters and fewer small satellite structures. The pipetting gels also supported lower\u2010curvature, more linear capillary networks that bridged multiple droplets, likely due to reduced entrapment in large voids compared to vortexed gels. These findings suggest that in bulk granular gels, lymphatic tube formation is governed not by mechanical stiffness but by pore size and gel topology (periodicity). Understanding and optimizing these morphological parameters can inform future strategies in lymphatic tissue engineering and regenerative medicine.<\/jats:p>","DOI":"10.1002\/admi.202401037","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:36Z","timestamp":1745469276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tuning the Morphological Properties of Granular Hydrogels to Control Lymphatic Capillary Formation"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1944-1474","authenticated-orcid":false,"given":"Daniel","family":"Montes","sequence":"first","affiliation":[{"name":"Bioengineering Graduate Program University of Notre Dame  Notre Dame IN 46556 USA"},{"name":"Chemical and Biomolecular Engineering University of Notre Dame  Notre Dame IN 46556 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