{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:32:31Z","timestamp":1773261151649,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T00:00:00Z","timestamp":1487548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RC1HL100491"],"award-info":[{"award-number":["RC1HL100491"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["2T32HL094293"],"award-info":[{"award-number":["2T32HL094293"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["F32HL118976"],"award-info":[{"award-number":["F32HL118976"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Adv Materials Technologies"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Biodegradable vascular scaffolds (BVS) are novel treatments for obstructive atherosclerotic cardiovascular disease developed to overcome the limitations of traditional metallic drug\u2010eluting stents. The mechanical properties of bioabsorbable polymers used for the production of novel BVS are a key consideration for the clinical translation of this emerging technology. Herein, the authors describe the engineering of an in situ light\u2010activated vascular scaffold (ILVS) comprised of a biodegradable citric acid\u2010based elastomeric polymer, referred to as methacrylated polydiol citrate (mPDC) and a diazeniumdiolate chitosan nitric oxide donor (chitoNO). In vitro studies demonstrate that the mechanical properties of the ILVS can be tailored to meet or exceed those of commercially available self\u2010expanding bare metal stents (BMS). The radial compression strength of the ILVS is higher than that of a BMS despite undergoing degradation at physiologic conditions for 7 months. ILVS containing chitoNO provides sustained supraphysiologic levels of NO release. Finally, ILVS is successfully cast in porcine arteries ex vivo using a custom designed triple balloon catheter, demonstrating translational potential. In conclusion, these data demonstrate the ability of an ILVS to provide tunable mechanical properties and drug\u2010delivery capabilities for the vasculature and thereby support mPDC as a promising material for the development of novel BVS platforms.<\/jats:p>","DOI":"10.1002\/admt.201600243","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T12:12:25Z","timestamp":1487679145000},"source":"Crossref","is-referenced-by-count":7,"title":["A Tailorable In Situ Light\u2010Activated Biodegradable Vascular Scaffold"],"prefix":"10.1002","volume":"2","author":[{"given":"Mazen S.","family":"Albaghdadi","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology Feinberg School of Medicine Northwestern University  Chicago IL 60611 USA"},{"name":"Simpson Querrey Institute for BioNanotechnology Northwestern University  Chicago IL 60611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Biomedical Engineering Department Northwestern University  Evanston IL 60208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica H.","family":"Brown","sequence":"additional","affiliation":[{"name":"Simpson Querrey Institute for BioNanotechnology Northwestern University  Chicago IL 60611 USA"},{"name":"Department of Surgery Feinberg School of Medicine Northwestern University  Chicago IL 60611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel A.","family":"Mansukhani","sequence":"additional","affiliation":[{"name":"Simpson Querrey Institute for BioNanotechnology Northwestern University  Chicago IL 60611 USA"},{"name":"Department of Surgery Feinberg School of Medicine Northwestern University  Chicago IL 60611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo A.","family":"Ameer","sequence":"additional","affiliation":[{"name":"Simpson Querrey Institute for BioNanotechnology Northwestern University  Chicago IL 60611 USA"},{"name":"Biomedical Engineering Department Northwestern University  Evanston IL 60208 USA"},{"name":"Department of Surgery Feinberg School of Medicine Northwestern University  Chicago IL 60611 USA"},{"name":"Chemistry of Life Processes Institute Northwestern University  Evanston IL 60208 USA"},{"name":"International Institute for Nanotechnology Northwestern University  Evanston IL 60208 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melina R.","family":"Kibbe","sequence":"additional","affiliation":[{"name":"Simpson Querrey Institute for BioNanotechnology Northwestern University  Chicago IL 60611 USA"},{"name":"Department of Surgery Feinberg School of Medicine Northwestern University  Chicago IL 60611 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3859"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.034"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61672-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-11-1416"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.07.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr466"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.08.016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.041"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5IFA3"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3bm00169e"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12388971"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.10.048"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114081"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.11.4651"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91481-4"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.201600138"},{"key":"e_1_2_6_20_1","first-page":"679","volume":"24","author":"Hanna E. B.","year":"2012","journal-title":"J. Invasive Cardiol."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-009-9601-z"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.026"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-008-9472-8"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.09.009"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.060"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00979-4"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.024"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.06.018"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.11.011"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4027661"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4003319"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.10.005"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.12.2995"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc3101.092214"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.031"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.714170"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/hh0102.102330"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb200274r"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01469a012"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.274.6.H2163"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.12.028"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050151i"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.045"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2014.10.028"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.11.015"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201000509"}],"container-title":["Advanced Materials Technologies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fadmt.201600243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/admt.201600243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T10:14:08Z","timestamp":1759745648000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/admt.201600243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,20]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1002\/admt.201600243"],"URL":"https:\/\/doi.org\/10.1002\/admt.201600243","archive":["Portico"],"relation":{},"ISSN":["2365-709X","2365-709X"],"issn-type":[{"value":"2365-709X","type":"print"},{"value":"2365-709X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,20]]},"article-number":"1600243"}}