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However, existing medical devices still rely on rigid electronics with many wires and separate components, which hinders wireless, comfortable, continuous monitoring of health\u2010related human motions. Advanced materials and system integration technologies are introduced that enable soft, active wireless, thin\u2010film bioelectronics. This low\u2010modulus, highly flexible wearable electronic system incorporates a nanomembrane wireless circuit and functional chip components enclosed by a soft elastomeric membrane. It can be gently and seamlessly mounted on the skin, while offering comfortable, highly sensitive and accurate detection of head movements. The wireless, skin\u2010like bioelectronic system (SKINTRONICS) is utilized for quantitative diagnostics of cervical dystonia (CD), which is characterized by involuntary abnormal head postures and repetitive head movements, sometimes with neck muscle pain. A set of analytical and experimental studies shows a soft system packaging, hard\u2013soft materials integration, and quantitative assessment of physiological signals detected by the SKINTRONICS. In vivo demonstration, involving 10 human subjects, finds the device feasible for use in CD measurement.<\/jats:p>","DOI":"10.1002\/admt.201900458","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T23:20:33Z","timestamp":1565997633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Soft Material\u2010Enabled, Active Wireless, Thin\u2010Film Bioelectronics for Quantitative Diagnostics of Cervical Dystonia"],"prefix":"10.1002","volume":"4","author":[{"given":"Young\u2010Tae","family":"Kwon","sequence":"first","affiliation":[{"name":"George W. Woodruff School of Mechanical Engineering Institute for Electronics and Nanotechnology Georgia Institute of Technology  Atlanta GA 30332 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongkuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Wichita State University  Wichita KS 67260 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamze Kilic","family":"Berkmen","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Human Genetics School of Medicine Emory University  GA 30322 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Ryoung","family":"Lim","sequence":"additional","affiliation":[{"name":"George W. 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Petit Institute for Bioengineering and Biosciences Center for Flexible and Wearable Electronics Advanced Research Institute for Materials Institute for Robotics and Intelligent Machines Georgia Institute of Technology  Atlanta GA 30332 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,16]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25579"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25244"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2007.02.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S152252"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2008.01111.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.09.023"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10127"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.01053.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2017.09.004"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70143-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0887-7"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26534"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mdc3.12131"},{"key":"e_1_2_7_14_1","volume-title":"29th Annual International Conference of the IEEE","author":"Parkka J.","year":"2007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/s130709183"},{"key":"e_1_2_7_16_1","volume-title":"30th Annual International Conference of the IEEE","author":"Chung W.\u2010Y.","year":"2008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-015-1395-3"},{"key":"e_1_2_7_18_1","first-page":"1","volume":"2013","author":"Kim H.","year":"2013","journal-title":"Evid. 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