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Bladder\u2010integrated implants are critically needed for restoring function, managing incontinence, or continuous bladder health monitoring. However, developing such neurotechnology remains challenging due to the bladder's large and dynamic volume changes (\u2248300%), which often cause mechanical incompatibility, tissue irritation, and limited long\u2010term efficacy. In this work, it is designed and evaluate highly stretchable, biocompatible, and bladder\u2010integrated implantable scaffolds that seamlessly conform to bladder expansion and contraction with negligible physiological impact using a biomimetic in vitro bladder model. This findings show that cross\u2010shaped scaffolds provide superior stretchability with negligible effect on bladder compliance. Compared to the control (no implants), these scaffolds exhibit minimum effect on bladder deformation even under 300% volume expansion. Long\u2010term mechanical tests confirm their positional stability, while cytocompatibility studies show high biocompatibility (&gt;99.5% cell viability), highlighting their potential usage for chronic implantation in urological applications. This work provides important insights into the development of advanced bladder\u2010integrated, highly stretchable bioelectronic implants for real\u2010time monitoring and neuromodulation of bladder dysfunction. The proposed novel engineering design and innovative approach lay a solid foundation for next\u2010generation bladder rehabilitation technologies.<\/jats:p>","DOI":"10.1002\/admt.202500552","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T03:26:49Z","timestamp":1751426809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design of Soft, Stretchable Bladder\u2010Integrated Scaffolds for Advanced Bioelectronic Implants"],"prefix":"10.1002","volume":"10","author":[{"given":"Yifan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Houston  Houston TX 77204 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2209-0755","authenticated-orcid":false,"given":"Ali","family":"Garmroudi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Houston  Houston TX 77204 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Houston  Houston TX 77204 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Zimmern","sequence":"additional","affiliation":[{"name":"Department of Urology The University of Texas Southwestern  Dallas TX 75390 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3303-0778","authenticated-orcid":false,"given":"Zhengwei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Houston  Houston TX 77204 USA"},{"name":"Department of Biomedical Sciences, The Tilman J. 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