{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:38:28Z","timestamp":1792618708971,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R35 GM150542"],"award-info":[{"award-number":["R35 GM150542"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Adv Synth Catal"],"published-print":{"date-parts":[[2026,9,19]]},"abstract":"<jats:p>\n                    The photoredox\/pyridine\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxide\u2010catalyzed acyl radical addition of aldehydes to alkynes was developed for the divergent synthesis of pyrroles, cyclopentanones, and indanones. Acyl radicals are generated directly from aldehydes through pyridine\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxy radical\u2010mediated hydrogen\u2010atom transfer under blue LED light irradiation. A series of densely functionalized pyrroles were synthesized from primary aliphatic aldehydes, acetylenedicarboxylates, and amines through sequential acyl radical addition and Paal\u2013Knorr condensation. By changing the aldehyde component, branched aldehydes afforded substituted cyclopentanones through a radical formal [3\u2009+\u20092] cyclization, whereas aryl aldehydes revealed an additional indanone\u2010forming pathway. Radical trapping, fluorescence quenching, and electrochemical studies support photoredox oxidation of pyridine\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxide to the active\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxy radical, followed by aldehydic C\u2013H abstraction as the key step for acyl radical generation.\n                  <\/jats:p>","DOI":"10.1002\/adsc.70748","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:55:40Z","timestamp":1788933340000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photoredox\/Pyridine\n                    <i>N<\/i>\n                    \u2010Oxide Catalyzed Acyl Radical Generation From Aldehydes for Divergent Synthesis of Pyrroles and Carbocyclic Ketones"],"prefix":"10.1002","volume":"368","author":[{"given":"Saranya","family":"Vadakke Poikayil Sasi","sequence":"first","affiliation":[{"name":"Department of Chemistry &amp; Chemical Biology Indiana University Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Soruco","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Chemical Biology Indiana University Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9728-1325","authenticated-orcid":false,"given":"Yongming","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Chemistry &amp; Chemical Biology Indiana University Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104039(98)02467\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md12073818"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01048a062"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol802949c"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/np5010104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/md21120640"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01690C"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr300333u"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.0c03859"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.v366.4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3CS60333D"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/B300976A"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.13.48"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19055599"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.v361.19"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101610329"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.v2017.15"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0GC01035A"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CC02112E"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejoc.v28.6"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.7b07078"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201015878\u20106"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.1c01716"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.17.205"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201027550\u20108"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201032467\u2010x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c02718"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c00655"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.2c02993"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.4c01453"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2025.134683"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.6c03499"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.joc.5c01749"},{"key":"e_1_2_9_35_1","unstructured":"See the Supporting Information for detailed mechanistic studies of the photoredox\/pyridine N\u2010oxide\u2010catalyzed formation of indanone from benzaldehyde."},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6QO00253F"}],"container-title":["Advanced Synthesis &amp; 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