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Distinct from central and effector memory T cells, T\n                    <jats:sub>RM<\/jats:sub>\n                    cells take up residence in home tissues such as the lung or urogenital tract and are ideally positioned to respond quickly to pathogen encounter. T\n                    <jats:sub>RM<\/jats:sub>\n                    are found to play a role in the immune response against many globally important infectious diseases for which new or improved vaccines are needed, including influenza and tuberculosis. It is also increasingly clear that T\n                    <jats:sub>RM<\/jats:sub>\n                    play a pivotal role in cancer immunity. Thus, vaccines that can generate this memory T cell population are highly desirable. The field of immunoengineering\u2014that is, the application of engineering principles to study the immune system and design new and improved therapies that harness or modulate immune responses\u2014is ideally poised to provide solutions to this need for next\u2010generation T\n                    <jats:sub>RM<\/jats:sub>\n                    vaccines. This review covers recent developments in vaccine technologies for generating T\n                    <jats:sub>RM<\/jats:sub>\n                    and protecting against infection and cancer, including viral vectors, virus\u2010like particles, and synthetic and natural biomaterials. In addition, it offers critical insights on the future of engineering vaccines for tissue\u2010resident memory T\u00a0cells.\n                  <\/jats:p>","DOI":"10.1002\/adtp.202000230","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T09:04:43Z","timestamp":1611133483000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Engineering Vaccines for Tissue\u2010Resident Memory T Cells"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8892-7262","authenticated-orcid":false,"given":"Frances C.","family":"Knight","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville TN 37235 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9144-2634","authenticated-orcid":false,"given":"John 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