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Microneedle (MN) patches can increase coverage by easing logistics through simplified administration and improved stability. This study demonstrates the thermostability of a bivalent measles and rubella vaccine MN patch. The data show that rubella vaccine stability requires pH buffering during drying; potassium phosphate buffer at neutral pH is optimal for both vaccines. Screening 43 excipients for their ability to retain potency during drying and storage yields sucrose\u2010threonine\u2010potassium phosphate buffer formulation at pH 7.5 as an optimal formulation. MN patches made with this formulation have no significant loss of vaccine titer after 1 month and remain within a one log<jats:sub>10<\/jats:sub> titer loss cutoff after 3\u20134 months at 5, 25, and 40 \u00b0C. Finally, these patches are shown to be immunogenic in juvenile rhesus macaques. This work demonstrates the potential for MN patches for measles and rubella vaccination to be removed from the cold chain, which is expected to decrease vaccine cost and wastage, and increase vaccination coverage.<\/jats:p>","DOI":"10.1002\/adtp.202100095","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T05:55:35Z","timestamp":1627451735000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Thermostability of Measles and Rubella Vaccines in a Microneedle Patch"],"prefix":"10.1002","volume":"4","author":[{"given":"Jessica C.","family":"Joyce","sequence":"first","affiliation":[{"name":"Wallace H. 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